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Literature summary extracted from

  • Abbruzzese, A.; Park, M.H.; Beninati, S.; Folk, J.E.
    Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide (1989), Biochim. Biophys. Acta, 997, 248-255.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 1,10-Diaminodecane 94% of initial activity at 2 mM Rattus norvegicus
1.14.99.29 1,3-diaminopropane 86% of initial activity at 0.5 mM Rattus norvegicus
1.14.99.29 1,6-diaminohexane 97% of initial activity at 2 mM Rattus norvegicus
1.14.99.29 1,7-Diaminoheptane 91% of initial activity at 2 mM Rattus norvegicus
1.14.99.29 1,8-diaminooctane 93% of initial activity at 2 mM Rattus norvegicus
1.14.99.29 cadaverine 87% of initial activity at 0.5 mM Rattus norvegicus
1.14.99.29 caldine 47% of initial activity at 0.5 mM Rattus norvegicus
1.14.99.29 Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys competitive inhibition Cricetulus griseus
1.14.99.29 additional information no inhibition at 2 mM N-(2-cyanopropyl)-3-cyanopropylamine Rattus norvegicus
1.14.99.29 N-(2-cyanoethyl)butane-1,4-diamine 80% of initial activity at 2 mM Rattus norvegicus
1.14.99.29 N-(3-cyanopropyl)propane-1,3-diamine 79% of initial activity at 2 mM Rattus norvegicus
1.14.99.29 putrescine 85% of initial activity at 0.5 mM Rattus norvegicus
1.14.99.29 spermidine 58% of initial activity at 0.5 mM Rattus norvegicus
1.14.99.29 spermine 41% of initial activity at 0.5 mM Rattus norvegicus
1.14.99.29 thermine 35% of initial activity at 0.5 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Cricetulus griseus
-
-
-
1.14.99.29 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.29 ovary
-
 Cricetulus griseus
-
1.14.99.29 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Cricetulus griseus N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?
1.14.99.29 N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Rattus norvegicus N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.99.29 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.99.29 7 7.5 in 20 mM Tris buffer Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.99.29 0.25
-
 spermine competitive inhibition Rattus norvegicus
1.14.99.29 0.44
-
 Lys-Thr-Gly-deoxyhypusine-His-Gly-His-Ala-Lys competitive inhibition Cricetulus griseus