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Literature summary extracted from

  • Ryder, N.S.; Dupont, M.C.
    Properties of a particulate squalene epoxidase from Candida albicans (1984), Biochim. Biophys. Acta, 794, 466-471.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.17 2-heptyl-4-hydroxyquinoline N-oxide 0.1 mM, 236% stimulation Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.17 4-hydroxymercuribenzoate 1 mM, 35% inhibition Candida albicans
1.14.14.17 antimycin A 0.1 mM, 44% inhibition Candida albicans
1.14.14.17 bovine serum albumin
-
 Candida albicans
1.14.14.17 chloromercuriphenylsulfonate 1 mM, 35% inhibition Candida albicans
1.14.14.17 Cu2+ 5 mM, 99% inhibition Candida albicans
1.14.14.17 deoxycholate
-
 Candida albicans
1.14.14.17 N-ethylmaleimide 1 mM, 35% inhibition Candida albicans
1.14.14.17 rotenone 0.1 mM, 67% inhibition Candida albicans
1.14.14.17 Triton X-100
-
 Candida albicans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.17 0.05
-
 squalene
-
 Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.17 microsome
-
 Candida albicans
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.17 Candida albicans
-
-
-

Storage Stability

EC Number Storage Stability Organism
1.14.14.17 -20°C, 5 d, 75% loss of activity Candida albicans
1.14.14.17 stable for several months in liquid nitrogen Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.17 squalene + NAD(P)H + O2
-
 Candida albicans (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.17 FAD required for activity Candida albicans
1.14.14.17 additional information FMN cannot replace FAD as cofactor Candida albicans