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Literature summary extracted from

  • Ono, T.; Imai, Y.
    Squalene epoxidase from rat liver microsomes (1985), Methods Enzymol., 110, 375-380.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.17 0.005
-
FAD
-
Rattus norvegicus
1.14.14.17 0.013
-
squalene
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.17 membrane
-
Rattus norvegicus 16020
-
1.14.14.17 microsome
-
Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.17
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.17 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.14.17 0.00619
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.14.14.17 -70°C, 50 mM Tris-HCl buffer, pH 7.4, 0.5% Triton X-100, several weeks Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.17 (3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O
-
Rattus norvegicus squalene + FADH2 + O2
-
r
1.14.14.17 squalene + NAD(P)H + O2
-
Rattus norvegicus (S)-squalene-2,3-epoxide + NADP+ + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.14.14.17 monomer
-
Rattus norvegicus
1.14.14.17 More enzyme system consists of squalene epoxidase which is distinct from hemoproteins such as cytochrome P-450 isozymes, and a flavoprotein identical with NADPH-cytochrome P-450 reductase Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.14.17 0.0055
-
squalene
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.17 FAD
-
Rattus norvegicus