Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jordan, D.B.
    Squalene oxidase: the elusive flavoenzyme of sterol biosynthesis (1991), Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York, , 865-868.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.17 0.00043
-
 FAD
-
 Rattus norvegicus
1.14.14.17 0.00085
-
 1-carba-1-deaza-FAD
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.17 squalene + electron donor + O2 Rattus norvegicus first oxygenase and last nonsterol reaction of sterol biosynthesis (S)-squalene-2,3-epoxide + oxidized electron donor + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.17 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.17 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.17 (3S)-2,3-epoxy-2,3-dihydrosqualene + 1-carba-1-deaza-FAD + H2O
-
 Rattus norvegicus squalene + 1-carba-1-deaza-FADH2 + O2
-
 r
1.14.14.17 (3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O
-
 Rattus norvegicus squalene + FADH2 + O2
-
 r
1.14.14.17 squalene + electron donor + O2 first oxygenase and last nonsterol reaction of sterol biosynthesis Rattus norvegicus (S)-squalene-2,3-epoxide + oxidized electron donor + H2O
-
 ?
1.14.14.17 squalene + NAD(P)H + O2
-
 Rattus norvegicus (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.17 1-Carba-1-deazaFAD can replace FAD as cofactor Rattus norvegicus
1.14.14.17 FAD flavoprotein Rattus norvegicus
1.14.14.17 additional information 5-carba-5-deazaFAD cannot replace FAD as cofactor Rattus norvegicus