EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | adenyl-5'-yl-imidodiphosphate | can replace ATP as activator of CDP and UDP reduction | Mus musculus | |
1.17.4.1 | ADP | - |
Mus musculus | |
1.17.4.1 | dGDP | 40% less effective than dGTP | Mus musculus | |
1.17.4.1 | dGTP | activation of ADP reduction | Mus musculus | |
1.17.4.1 | additional information | overview: nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | dATP | inhibition of CDP reduction; inhibition of CDP, UDP, GDP and ADP reduction; noncompetitive inhibition vs. ADP, GDP and CDP | Mus musculus | |
1.17.4.1 | dGTP | inhibition of GDP reduction | Mus musculus | |
1.17.4.1 | dTTP | inhibition of ADP- CDP- and UDP reduction | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | additional information | model of enzyme regulation by nucleoside 5'-triphosphates | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.1 | Mus musculus | - |
Ehrlich ascites tumor cells | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.4.1 | Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
1.17.4.1 | L-1210 cell | - |
Mus musculus | - |
1.17.4.1 | L-cell | cell line | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Mus musculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir |