EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | adenyl-5'-yl-imidodiphosphate | maximal activation of CDP reduction at 4 mM | Mus musculus | |
1.17.4.1 | ATP | reduction of CDP is dependent on ATP or adenyl-5'-yl iminodiphosphate | Mus musculus | |
1.17.4.1 | dihydrolipoic acid | slight stimulation | Mus musculus | |
1.17.4.1 | dithiothreitol | slight activation | Mus musculus | |
1.17.4.1 | dTTP | stimulation of GDP reduction | Mus musculus | |
1.17.4.1 | EDTA | reversible stimulation of GDP reduction, irreversible inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | additional information | enzyme of cells first treated with 2,6-dichlorophenolindophenol has a complete dependence on NADPH which can also be met by dithiothreitol or dihydrolipoic acid | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | ATP | 4 mM, 50% inhibition of GDP reduction in the presence of dTTP | Mus musculus | |
1.17.4.1 | bathophenanthroline sulfonate | 5 mM, almost complete inhibition of CDP and GDP reduction | Mus musculus | |
1.17.4.1 | dATP | 0.0033 mM, 50% inhibition of CDP reduction, 0.0036 mM, 50% inhibition of GDP reduction; inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | dCTP | 1 mM, 50% inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | dGTP | 0.08 mM, 50% inhibition of CDP reduction, 0.19 mM, 50% inhibition of GDP reduction; inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | dTTP | 0.2 mM, 50% inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | EDTA | reversible stimulation of GDP reduction, irreversible inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | Hydroxyurea | 1 mM, 98 and 81% inhibition of CDP and GDP reduction respectively | Mus musculus | |
1.17.4.1 | Mg2+ | 1-5 mM, 10-20% inhibition of GDP reduction; inhibition of CDP reduction | Mus musculus | |
1.17.4.1 | sodium arsenite | 0.025 mM, almost complete inhibition of CDP reduction, 86% inhibition of GDP reduction | Mus musculus | |
1.17.4.1 | Thenoyltrifluoroacetone | 5 mM, almost complete inhibition of CDP and GDP reduction | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.4.1 | 0.05 | - |
CDP | - |
Mus musculus | |
1.17.4.1 | 0.24 | - |
GDP | - |
Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.1 | Mus musculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.17.4.1 | Novikoff ascites tumor cells, partial | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.1 | ADP + reduced thioredoxin | - |
Mus musculus | 2'-deoxy-ADP + oxidized thioredoxin + H2O | - |
ir | |
1.17.4.1 | CDP + reduced thioredoxin | - |
Mus musculus | 2'-deoxy-CDP + oxidized thioredoxin + H2O | - |
ir | |
1.17.4.1 | GDP + reduced thioredoxin | - |
Mus musculus | 2'-deoxy-GDP + oxidized thioredoxin + H2O | - |
ir | |
1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Mus musculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
1.17.4.1 | UDP + reduced thioredoxin | - |
Mus musculus | 2'-deoxy-UDP + oxidized thioredoxin + H2O | - |
ir |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | NADPH | slight stimulation | Mus musculus |