EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.1 | bovine serum albumin | stimulates activity in the microsomal fraction | Rattus norvegicus | |
1.14.19.1 | Insulin | causes 5fold increace of activity | Gallus gallus | |
1.14.19.1 | protein | non-substrate soluble cytosolic protein stimulates | Rattus norvegicus | |
1.14.19.1 | stearoyl-CoA-binding protein | stimulates activity in the crude microsomal fraction | Rattus norvegicus | |
1.14.19.1 | thyroxine | - |
Gallus gallus | |
1.14.19.1 | triiodothyronine | - |
Gallus gallus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.1 | cycloheximide | - |
Gallus gallus | |
1.14.19.1 | ethyl linoleate | - |
Rattus norvegicus | |
1.14.19.1 | ethyl palmitate | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.19.1 | endoplasmic reticulum | - |
Gallus gallus | 5783 | - |
1.14.19.1 | endoplasmic reticulum | bound | Rattus norvegicus | 5783 | - |
1.14.19.1 | microsome | membrane bound | Gallus gallus | - |
- |
1.14.19.1 | microsome | membrane bound | Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.1 | Fe2+ | - |
Gallus gallus | |
1.14.19.1 | Fe2+ | contains one atom of non-heme iron per enzyme molecule, catalytic function | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.19.1 | 53000 | - |
x * 53000 | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.19.1 | stearate + AH2 + O2 | Rattus norvegicus | biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate | oleate + A + 2 H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.19.1 | Gallus gallus | - |
embryo | - |
1.14.19.1 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.19.1 | partially | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.14.19.1 | stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | introduction of double bonds at fixed positions from the carboxyl group of the fatty acid. D-hydrogen atoms are removed during desaturation. Mixed-function oxidase, acting via hydroxy acid intermediates. Acetyl-CoA desaturase, carboxylase and fatty acid synthetase are all controlled together as a unit and influenced by dietary components | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.19.1 | liver | - |
Gallus gallus | - |
1.14.19.1 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.19.1 | heptadecanoate + AH2 + O2 | low activity | Rattus norvegicus | ? | - |
? | |
1.14.19.1 | nonadecanoate + AH2 + O2 | low activity | Rattus norvegicus | ? | - |
? | |
1.14.19.1 | stearate + AH2 + O2 | maximum activity | Rattus norvegicus | oleate + A + 2 H2O | - |
? | |
1.14.19.1 | stearate + AH2 + O2 | biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate | Rattus norvegicus | oleate + A + 2 H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.19.1 | ? | - |
Gallus gallus |
1.14.19.1 | ? | x * 53000 | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.1 | flavin | flavin-containing NADH-cytochrome b5 reductase (EC 1.6.2.2.) | Rattus norvegicus | |
1.14.19.1 | heme | heme-containing cytochrome b5 | Rattus norvegicus | |
1.14.19.1 | NADH | - |
Gallus gallus | |
1.14.19.1 | NADH | - |
Rattus norvegicus |