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Literature summary extracted from

  • Voltattorni, C.B.; Giartosio, A.; Turano, C.
    Aromatic-L-amino acid decarboxylase from pig kidney (1987), Methods Enzymol., 142, 179-187.
    View publication on PubMed

General Stability

EC Number General Stability Organism
4.1.1.28 graduall decrease in activity by repeated freezing and thawing Sus scrofa
4.1.1.28 no loss of activity after lyophilization Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.28 2,3,4-Trihydroxybenzylhydrazine
-
 Sus scrofa
4.1.1.28 Amino-oxyacetate
-
 Sus scrofa
4.1.1.28 BH4
-
 Sus scrofa
4.1.1.28 Dithiobisnitrobenzoate
-
 Sus scrofa
4.1.1.28 DL-alpha-Difluoromethyl-beta-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa
4.1.1.28 DL-alpha-Monofluoromethyl-beta-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa
4.1.1.28 hydroxylamine
-
 Sus scrofa
4.1.1.28 iodoacetamide
-
 Sus scrofa
4.1.1.28 L-alpha-Methyl-alpha-hydrazino-3,4-dihydroxyphenylpropionic acid
-
 Sus scrofa
4.1.1.28 mercuribenzoate
-
 Sus scrofa
4.1.1.28 NEM
-
 Sus scrofa
4.1.1.28 Semicarbazide
-
 Sus scrofa
4.1.1.28 Thiosemicarbazide
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.28 0.12
-
 L-o-Tyr
-
 Sus scrofa
4.1.1.28 0.18
-
 3,4-dihydroxyphenylalanine
-
 Sus scrofa
4.1.1.28 0.23
-
 5-hydroxytryptophan
-
 Sus scrofa
4.1.1.28 0.52
-
 L-m-Tyr
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.28 50000
-
 2 * 50000, SDS-PAGE Sus scrofa
4.1.1.28 103000
-
 ultracentrifugation analysis Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.28
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.28 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.28 additional information
-
-
 Sus scrofa

Storage Stability

EC Number Storage Stability Organism
4.1.1.28 -20°C, 0.1 M potassium phosphate buffer, 0.1 mM dithiothreitol, stable for at least 2 months Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 3,4-Dihydroxyphenylalanine
-
 Sus scrofa 3-Hydroxytyramine + CO2
-
 ?
4.1.1.28 5-Hydroxytryptophan
-
 Sus scrofa Serotonin + CO2
-
 ?
4.1.1.28 m-Tyr
-
 Sus scrofa ?
-
 ?
4.1.1.28 o-Tyr
-
 Sus scrofa ?
-
 ?
4.1.1.28 Tyr
-
 Sus scrofa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.28 dimer 2 * 50000, SDS-PAGE Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.28 6.8
-
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.28 pyridoxal 5'-phosphate 1 mol of pyridoxal 5'-phosphate is bound to the epsilon-amino group of a lysyl residue of the apoenzyme Sus scrofa