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Literature summary extracted from

  • Tran, V.T.; Snyder, S.H.
    Histidine decarboxylase. Purification from fetal rat liver, immunologic properties, and histochemical localization in brain and stomach (1981), J. Biol. Chem., 256, 680-686.
    View publication on PubMed

General Stability

EC Number General Stability Organism
4.1.1.22 after dialysis for 48 h against buffer containing 1 mM semicarbazide, about 50% loss of activity, full recovery by adding pyridoxal 5'-phosphate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
4.1.1.22 alpha-Fluoromethylhistidine the (S)-isomer is a suicide substrate inhibitor, the (R)-isomer is an at least 10times less potent inhibitor Rattus norvegicus
4.1.1.22 Co(NO3)2 slight Rattus norvegicus
4.1.1.22 HgCl2
-
 Rattus norvegicus
4.1.1.22 ZnCl2
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.22 additional information
-
 additional information between pH 6 and pH 9 the Km-value for L-His declines from 1 mM to about 0.01 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.22 66000
-
 1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE Rattus norvegicus
4.1.1.22 145000
-
 1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE Rattus norvegicus
4.1.1.22 210000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 brain
-
 Rattus norvegicus
-
4.1.1.22 gastric mucosa
-
 Rattus norvegicus
-
4.1.1.22 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 additional information
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
4.1.1.22 -70°C, no loss of activity for at least 6 months Rattus norvegicus
4.1.1.22 4°C, stable for about 1 week Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-His
-
 Rattus norvegicus Histamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 dimer 1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.8
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate after dialysis for 48 h against buffer containing 1 mM semicarbazide, about 50% loss of activity, full recovery by adding pyridoxal 5'-phosphate. Km: 0.001 mM Rattus norvegicus