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Literature summary extracted from
- Purification and some properties of L-glutamate decarboxylase from human brain (1978), Eur. J. Biochem., 86, 143-152.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.15 | 2-oxoglutarate | - |
Homo sapiens |  |
| 4.1.1.15 | 3,4-dihydroxyphenylacetic acid | - |
Homo sapiens | |
| 4.1.1.15 | 3-Hydroxytyramine | - |
Homo sapiens | |
| 4.1.1.15 | 3-Mercaptopropionic acid | - |
Homo sapiens | |
| 4.1.1.15 | Asp | - |
Homo sapiens | |
| 4.1.1.15 | D-Glu | - |
Homo sapiens | |
| 4.1.1.15 | DL-alpha-Aminoadipic acid | - |
Homo sapiens | |
| 4.1.1.15 | DL-Penicillamine | - |
Homo sapiens | |
| 4.1.1.15 | KI | - |
Homo sapiens | |
| 4.1.1.15 | L-Cysteine hydrochloride | - |
Homo sapiens | |
| 4.1.1.15 | L-cysteine sulfinic acid | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.15 | 1.28 | - |
L-Glu | pH 6.8 | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 67000 | - |
2 * 67000, SDS-PAGE | Homo sapiens |
| 4.1.1.15 | 100000 | - |
gel filtration | Homo sapiens |
| 4.1.1.15 | 140000 | - |
nondenaturing PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.15 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.15 | partial | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.15 | brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.15 | L-Glu | - |
Homo sapiens | 4-Aminobutanoate + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.15 | dimer | 2 * 67000, SDS-PAGE | Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 50 | - |
50% loss of activity after 24 min | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 6.8 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 6 | 7.8 | pH 6.0: about 65% of maximal activity, pH 7.8: about 35% of maximal activity | Homo sapiens |
| 4.1.1.15 | 6.4 | 7.8 | pH 6.4: about 50% of maximal activity, pH 7.8: about 70% of maximal activity | Homo sapiens |
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Release 2023.1 (January 2023)
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