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Literature summary extracted from

  • Moore, R.J.; Wilson, J.D.
    Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities (1976), J. Biol. Chem., 251, 5895-5900.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 fibroblast cultured Homo sapiens
-
1.3.1.22 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 20-alpha-hydroxypregn-4-ene-3one + NADPH
-
 Homo sapiens 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Homo sapiens 5-alpha-cholestan-3-one + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 5.5
-
 human: 2 forms, 1. pH-optimum 5.5 (only in fibroblasts derived from genital skin), 2. pH-optimum 7-9 (in both genital and nongenital skin regions and in fibroblast from all skin regions) Homo sapiens
1.3.1.22 7 9 human: 2 forms, 1. pH-optimum 5.5 (only in fibroblasts derived from genital skin), 2. pH-optimum 7-9 (in both genital and nongenital skin regions and in fibroblast from all skin regions) Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Homo sapiens