BRENDA - Enzyme Database

Carboligase activity of alpha-ketoglutarate dehydrogenase

Schlossberg, M.A.; Bloom, R.J.; Richert, D.A.; Westerfeld, W.W.; Biochemistry 9, 1148-1153 (1970)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.2.1.5
Bos taurus
-
bovine
-
2.2.1.5
Rattus norvegicus
-
rat
-
Purification (Commentary)
EC Number
Commentary
Organism
2.2.1.5
-
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.2.1.5
brain
-
Bos taurus
-
2.2.1.5
brain
-
Rattus norvegicus
-
2.2.1.5
heart
distribution in rat tissues
Rattus norvegicus
-
2.2.1.5
heart
-
Bos taurus
-
2.2.1.5
kidney
-
Bos taurus
-
2.2.1.5
kidney
-
Rattus norvegicus
-
2.2.1.5
liver
-
Bos taurus
-
2.2.1.5
liver
-
Rattus norvegicus
-
2.2.1.5
muscle
-
Bos taurus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.2.1.5
0.8
-
-
Bos taurus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.2.1.5
2-oxoglutarate
decarboxylation
395928
Bos taurus
? + CO2
-
-
-
-
2.2.1.5
2-oxoglutarate + acetaldehyde
-
395928
Bos taurus
5-hydroxy-4-oxohexanoate + CO2
-
-
-
-
2.2.1.5
2-oxoglutarate + glyoxylate
-
395928
Rattus norvegicus
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
2.2.1.5
2-oxoglutarate + glyoxylate
-
395928
Bos taurus
2-hydroxy-3-oxohexandioate + CO2
also 2,3-dihydroxy-4-ketopimelic acid
395928
Bos taurus
-
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.2.1.5
37
-
enzyme assay at
Bos taurus
2.2.1.5
37
-
enzyme assay at
Rattus norvegicus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.2.1.5
7.1
-
enzyme assay at
Bos taurus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.2.1.5
thiamine diphosphate
-
Bos taurus
2.2.1.5
thiamine diphosphate
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.2.1.5
thiamine diphosphate
-
Bos taurus
2.2.1.5
thiamine diphosphate
-
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.2.1.5
-
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.2.1.5
brain
-
Bos taurus
-
2.2.1.5
brain
-
Rattus norvegicus
-
2.2.1.5
heart
distribution in rat tissues
Rattus norvegicus
-
2.2.1.5
heart
-
Bos taurus
-
2.2.1.5
kidney
-
Bos taurus
-
2.2.1.5
kidney
-
Rattus norvegicus
-
2.2.1.5
liver
-
Bos taurus
-
2.2.1.5
liver
-
Rattus norvegicus
-
2.2.1.5
muscle
-
Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.2.1.5
0.8
-
-
Bos taurus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.2.1.5
2-oxoglutarate
decarboxylation
395928
Bos taurus
? + CO2
-
-
-
-
2.2.1.5
2-oxoglutarate + acetaldehyde
-
395928
Bos taurus
5-hydroxy-4-oxohexanoate + CO2
-
-
-
-
2.2.1.5
2-oxoglutarate + glyoxylate
-
395928
Rattus norvegicus
2-hydroxy-3-oxohexandioate + CO2
-
-
-
-
2.2.1.5
2-oxoglutarate + glyoxylate
-
395928
Bos taurus
2-hydroxy-3-oxohexandioate + CO2
also 2,3-dihydroxy-4-ketopimelic acid
395928
Bos taurus
-
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.2.1.5
37
-
enzyme assay at
Bos taurus
2.2.1.5
37
-
enzyme assay at
Rattus norvegicus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.2.1.5
7.1
-
enzyme assay at
Bos taurus