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Literature summary extracted from

  • Schlossberg, M.A.; Bloom, R.J.; Richert, D.A.; Westerfeld, W.W.
    Carboligase activity of alpha-ketoglutarate dehydrogenase (1970), Biochemistry, 9, 1148-1153.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.5 Bos taurus
-
 bovine
-
2.2.1.5 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.2.1.5
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.2.1.5 brain
-
 Rattus norvegicus
-
2.2.1.5 brain
-
 Bos taurus
-
2.2.1.5 heart
-
 Bos taurus
-
2.2.1.5 heart distribution in rat tissues Rattus norvegicus
-
2.2.1.5 kidney
-
 Rattus norvegicus
-
2.2.1.5 kidney
-
 Bos taurus
-
2.2.1.5 liver
-
 Rattus norvegicus
-
2.2.1.5 liver
-
 Bos taurus
-
2.2.1.5 muscle
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.2.1.5 0.8
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.5 2-oxoglutarate decarboxylation Bos taurus ? + CO2
-
 ?
2.2.1.5 2-oxoglutarate + acetaldehyde
-
 Bos taurus 5-hydroxy-4-oxohexanoate + CO2
-
 ?
2.2.1.5 2-oxoglutarate + glyoxylate
-
 Rattus norvegicus 2-hydroxy-3-oxohexandioate + CO2
-
 ?
2.2.1.5 2-oxoglutarate + glyoxylate
-
 Bos taurus 2-hydroxy-3-oxohexandioate + CO2 also 2,3-dihydroxy-4-ketopimelic acid ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.2.1.5 37
-
 enzyme assay at Rattus norvegicus
2.2.1.5 37
-
 enzyme assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.2.1.5 7.1
-
 enzyme assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.5 thiamine diphosphate
-
 Rattus norvegicus
2.2.1.5 thiamine diphosphate
-
 Bos taurus