EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.2.1.6 | Ile | mild inhibition of isoenzyme I and III | Escherichia coli | |
2.2.1.6 | Ile | inhibition of isoenzyme I, no inhibition of isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.2.1.6 | Leu | no inhibition of isoenzyme I and III | Escherichia coli | |
2.2.1.6 | Leu | inhibition of isoenzyme I, no inhibition of isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.2.1.6 | Val | isoenzymes I and II are inhibited, isoenzyme II is not inhibited | Escherichia coli | |
2.2.1.6 | Val | isoenzymes I and II are inhibited, isoenzyme II is not inhibited | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.2.1.6 | pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme II is regulated by Leu, Ile and Val | ? | - |
? | |
2.2.1.6 | pyruvate | Escherichia coli | isoenzyme II is regulated by Leu, Ile and Val | ? | - |
? | |
2.2.1.6 | pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme II is regulated by Leu | ? | - |
? | |
2.2.1.6 | pyruvate | Escherichia coli | isoenzyme II is regulated by Leu | ? | - |
? | |
2.2.1.6 | pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
2.2.1.6 | pyruvate | Escherichia coli | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
2.2.1.6 | pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme I is regulated by Leu and Val | ? | - |
? | |
2.2.1.6 | pyruvate | Escherichia coli | isoenzyme I is regulated by Leu and Val | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.2.1.6 | Escherichia coli | - |
K-12 | - |
2.2.1.6 | Escherichia coli | - |
3 isoenzymes: I, II, and III | - |
2.2.1.6 | Escherichia coli | - |
isoenzyme I and III are expressed in wild type cells, isoenzyme II is cryptic | - |
2.2.1.6 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
3 isoenzymes: I, II, and III | - |
2.2.1.6 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
isoenzyme I and II are expressed in wild type cells, isoenzyme III is cryptic | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.2.1.6 | pyruvate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-acetolactate + CO2 | - |
? | |
2.2.1.6 | pyruvate | - |
Escherichia coli | 2-acetolactate + CO2 | - |
? | |
2.2.1.6 | pyruvate | isoenzyme II is regulated by Leu, Ile and Val | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2.2.1.6 | pyruvate | isoenzyme II is regulated by Leu, Ile and Val | Escherichia coli | ? | - |
? | |
2.2.1.6 | pyruvate | isoenzyme II is regulated by Leu | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2.2.1.6 | pyruvate | isoenzyme II is regulated by Leu | Escherichia coli | ? | - |
? | |
2.2.1.6 | pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2.2.1.6 | pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Escherichia coli | ? | - |
? | |
2.2.1.6 | pyruvate | isoenzyme I is regulated by Leu and Val | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2.2.1.6 | pyruvate | isoenzyme I is regulated by Leu and Val | Escherichia coli | ? | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.2.1.6 | 7 | - |
isoenzyme I | Salmonella enterica subsp. enterica serovar Typhimurium |
2.2.1.6 | 7 | - |
isoenzyme I | Escherichia coli |
2.2.1.6 | 8 | - |
isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium |
2.2.1.6 | 8 | - |
isoenzyme II | Escherichia coli |
2.2.1.6 | 9 | - |
isoenzyme III | Salmonella enterica subsp. enterica serovar Typhimurium |
2.2.1.6 | 9 | - |
isoenzyme III | Escherichia coli |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.2.1.6 | FAD | partial requirement for isoenzyme III | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.2.1.6 | FAD | absolutly required for isoenzyme I and II, no requirement for isoenzyme III | Escherichia coli |