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Literature summary extracted from

  • Fellmann, J.H.
    4-Hydroxyphenylpyruvate dioxygenase from avian liver (1987), Methods Enzymol., 142, 148-154.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 1,10-phenanthroline
-
 Gallus gallus
1.13.11.27 1-(2'-thionyl)-3,3,3-trifluoroacetone
-
 Gallus gallus
1.13.11.27 2,2'-bipyridyl
-
 Gallus gallus
1.13.11.27 2,4-Dihydroxyphenylpyruvate competitive Gallus gallus
1.13.11.27 2-Hydroxybenzaldehyde competitive Gallus gallus
1.13.11.27 2-Hydroxyphenylpyruvate competitive Gallus gallus
1.13.11.27 3-hydroxyphenylpyruvate competitive Gallus gallus
1.13.11.27 3-methoxy-4-hydroxyphenylpyruvate competitive Gallus gallus
1.13.11.27 bathophenanthroline
-
 Gallus gallus
1.13.11.27 Cupferron
-
 Gallus gallus
1.13.11.27 diethyldithiocarbamate
-
 Gallus gallus
1.13.11.27 Dithizone
-
 Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.27 Iron 0.88 mol of iron per mol of enzyme Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.27 49000
-
 2 * 49000, SDS-PAGE Gallus gallus
1.13.11.27 97000
-
 equilibrium sedimentation Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.27
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.27 8.5
-
-
 Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 3,4-dihydroxyphenylpyruvate + O2
-
 Gallus gallus ? + CO2
-
 ?
1.13.11.27 4-fluorophenylpyruvate + O2
-
 Gallus gallus 4-fluoro-2-hydroxyphenylacetate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Gallus gallus homogentisate + CO2
-
 ?
1.13.11.27 4-methylphenylpyruvate + O2 poor substrate Gallus gallus ? + CO2
-
 ?
1.13.11.27 phenylpyruvate + O2
-
 Gallus gallus 2-hydroxyphenylacetate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.27 dimer 2 * 49000, SDS-PAGE Gallus gallus