Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wilson, E.M.; Kornberg, H.L.
    Properties of crystalline L-aspartate 4-carboxy-lyase from Achromobacter sp. (1963), Biochem. J., 88, 578-587.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.12 2-oxoglutarate activates Achromobacter sp.
4.1.1.12 acetaldehyde activates Achromobacter sp.
4.1.1.12 Glyoxal activates Achromobacter sp.
4.1.1.12 glyoxylate activates Achromobacter sp.
4.1.1.12 oxalacetate activates Achromobacter sp.
4.1.1.12 pyruvate activates Achromobacter sp.

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.12
-
 Achromobacter sp.

General Stability

EC Number General Stability Organism
4.1.1.12 rapid loss of activity in dilute solution Achromobacter sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.12 beta-Ala weak Achromobacter sp.
4.1.1.12 DL-beta-Methylaspartate
-
 Achromobacter sp.
4.1.1.12 DL-erythro-beta-hydroxyaspartate
-
 Achromobacter sp.
4.1.1.12 DL-threo-beta-hydroxyaspartate
-
 Achromobacter sp.
4.1.1.12 L-Ala
-
 Achromobacter sp.
4.1.1.12 Maleate
-
 Achromobacter sp.
4.1.1.12 phosphate strong inhibition by phosphate buffers above pH 5.0 Achromobacter sp.
4.1.1.12 succinate
-
 Achromobacter sp.
4.1.1.12 Tartrate weak Achromobacter sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.12 0.08
-
 L-Asp
-
 Achromobacter sp.

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.12 Achromobacter sp.
-
-
-

Storage Stability

EC Number Storage Stability Organism
4.1.1.12 4°C, pH 7, stable in concentrated solution Achromobacter sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.12 L-Asp
-
 Achromobacter sp. L-Ala + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.12 3.5 6
-
 Achromobacter sp.

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
4.1.1.12 5
-
 rapid loss of activity Achromobacter sp.
4.1.1.12 7
-
 4°C, stable in concentrated solution Achromobacter sp.

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.12 pyridoxal 5'-phosphate bound to the enzyme probably in a reduced form Achromobacter sp.