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Literature summary extracted from
- Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase: implications for the antitumor effects of selenium (2002), J. Biol. Chem., 277, 9701-9706.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | cysteine | C-terminal redox active disulfide | Drosophila melanogaster |  |
| 1.8.1.9 | cysteine | C-terminal redox active disulfide | Homo sapiens | |
| 1.8.1.9 | cysteine | C-terminal redox active disulfide | Plasmodium falciparum | |
| 1.8.1.9 | cysteine | part of the active site | Drosophila melanogaster | |
| 1.8.1.9 | cysteine | part of the active site | Homo sapiens | |
| 1.8.1.9 | cysteine | part of the active site | Plasmodium falciparum | |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | C73S | recombinant, His-tagged | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | auranofin | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.9 | 0.018 | - |
methylseleninate | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Drosophila melanogaster | - |
recombinant | - |
| 1.8.1.9 | Homo sapiens | - |
- |
- |
| 1.8.1.9 | Mus musculus | - |
- |
- |
| 1.8.1.9 | Plasmodium falciparum | - |
recombinant | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Drosophila melanogaster | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Mus musculus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Plasmodium falciparum | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Drosophila melanogaster | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Plasmodium falciparum | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 1.8.1.9 | GSSG + NADPH | in presence of methylselenol | Homo sapiens | GSH + NADP+ | - |
r | |
| 1.8.1.9 | methylseleninate + H2O2 | - |
Drosophila melanogaster | ? | - |
? | |
| 1.8.1.9 | methylseleninate + H2O2 | - |
Mus musculus | ? | - |
? | |
| 1.8.1.9 | methylseleninate + H2O2 | - |
Plasmodium falciparum | ? | - |
? | |
| 1.8.1.9 | methylseleninate + H2O2 | in presence of methylseleninate | Homo sapiens | ? | - |
? | |
| 1.8.1.9 | methylseleninate + NADPH | also utilizes glutathione instead of NADPH | Homo sapiens | CH3SeH + NADP+ | - |
ir | |
| 1.8.1.9 | seleninate + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.8.1.9 | thioredoxin + NADP+ | - |
Mus musculus | thioredoxin disulfide + NADPH | - |
r | |
| 1.8.1.9 | thioredoxin + NADP+ | coupled assay with DTNB | Drosophila melanogaster | thioredoxin disulfide + NADPH | - |
r | |
| 1.8.1.9 | thioredoxin + NADP+ | coupled assay with DTNB | Homo sapiens | thioredoxin disulfide + NADPH | - |
r | |
| 1.8.1.9 | thioredoxin + NADP+ | coupled assay with DTNB | Plasmodium falciparum | thioredoxin disulfide + NADPH | - |
r | |
| 1.8.1.9 | thioredoxin + tert-butyl-hydroperoxide | in presence of methylseleninate, coupled assay | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | TrxR | - |
Drosophila melanogaster |
| 1.8.1.9 | TrxR | - |
Mus musculus |
| 1.8.1.9 | TrxR | - |
Homo sapiens |
| 1.8.1.9 | TrxR | - |
Plasmodium falciparum |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.9 | 12 | - |
methylseleninate | recombinant protein | Drosophila melanogaster | |
| 1.8.1.9 | 14 | - |
methylseleninate | - |
Mus musculus | |
| 1.8.1.9 | 23 | - |
methylseleninate | - |
Homo sapiens | |
| 1.8.1.9 | 31 | - |
methylseleninate | - |
Plasmodium falciparum | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | FAD | - |
Drosophila melanogaster | |
| 1.8.1.9 | FAD | - |
Mus musculus | |
| 1.8.1.9 | FAD | - |
Homo sapiens | |
| 1.8.1.9 | FAD | - |
Plasmodium falciparum | |
| 1.8.1.9 | NADPH | - |
Drosophila melanogaster | |
| 1.8.1.9 | NADPH | - |
Mus musculus | |
| 1.8.1.9 | NADPH | - |
Homo sapiens | |
| 1.8.1.9 | NADPH | - |
Plasmodium falciparum | |
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