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Literature summary extracted from

  • Varandani, P.T.; Nafz, M.A.
    Interaction of glutathione-insulin transhydrogenase (disulfide interchange enzyme) with phospholipids (1976), Biochim. Biophys. Acta, 438, 358-369.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.4.2 Phospholipids slight activation by all phospholipids tested except for phosphatidic acid and phosphatidylserine, highest activation by phosphatidylethanolamine Rattus norvegicus
1.8.4.2 Phospholipids slight activation by all phospholipids tested except for phosphatidic acid and phosphatidylserine, highest activation by phosphatidylethanolamine Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.2 lysophosphatidylcholine
-
 Bos taurus
1.8.4.2 lysophosphatidylcholine
-
 Rattus norvegicus
1.8.4.2 phosphatidic acid
-
 Bos taurus
1.8.4.2 phosphatidic acid
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.2 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Bos taurus
-
-
-
1.8.4.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 liver
-
 Rattus norvegicus
-
1.8.4.2 liver
-
 Bos taurus
-
1.8.4.2 pancreas
-
 Rattus norvegicus
-
1.8.4.2 pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 GSH + insulin
-
 Bos taurus GSSG + reduced insulin chain A and B
-
 ?
1.8.4.2 GSH + protein disulfide
-
 Rattus norvegicus GSSG + protein-dithiol
-
 ?
1.8.4.2 GSH + protein disulfide
-
 Bos taurus GSSG + protein-dithiol
-
 ?