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Literature summary extracted from

  • Tomizawa, H.H.
    Glutathione-insulin transhydrogenase (steer liver) (1971), Methods Enzymol., 17B, 515-519.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.2 Cu2+
-
 Bos taurus
1.8.4.2 Hg2+
-
 Bos taurus
1.8.4.2 N-acetyl-L-tyrosine ethyl ester
-
 Bos taurus
1.8.4.2 ribonuclease
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.4.2 additional information
-
 additional information
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Bos taurus
-
 steer
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.2 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 GSH + insulin
-
 Bos taurus GSSG + reduced insulin chain A and B
-
 ?
1.8.4.2 GSH + protein disulfide prolactin is a poor substrate Bos taurus GSSG + protein-dithiol
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.8.4.2 60
-
 30 min, 30% loss of activity Bos taurus
1.8.4.2 80
-
 30 min, about 60% loss of activity Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.4.2 7.5 8.5
-
 Bos taurus