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Literature summary extracted from
- Metabolism of insulin and glucagon. Glutathione-insulin transhydrogenase from microsomes of rat liver (1973), Eur. J. Biochem., 32, 27-35.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.8.4.2 | EDTA stabilizes during purification | Rattus norvegicus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.4.2 | 0.031 | - |
Insulin | - |
Rattus norvegicus | |
| 1.8.4.2 | 1.43 | - |
GSH | - |
Rattus norvegicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.2 | microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | 50000 | 55000 | gel filtration | Rattus norvegicus |
| 1.8.4.2 | 60000 | - |
SDS-PAGE, a 120000 MW protein also found | Rattus norvegicus |
| 1.8.4.2 | 120000 | - |
SDS-PAGE, MW 60000 determined for the main component | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.4.2 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | 458 | - |
purified enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.2 | GSH + protein disulfide | - |
Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | 7 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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