Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Varandani, P.T.
    Glutathione-insulin transhydrogenase (protein-disulfide interchange enzyme) (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 753-765.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.4.2 Chelating agents e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation Mus musculus
1.8.4.2 Chelating agents e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation Homo sapiens
1.8.4.2 Chelating agents e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation Rattus norvegicus
1.8.4.2 Chelating agents e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation Bos taurus
1.8.4.2 EDTA and other chelating agents activate Mus musculus
1.8.4.2 EDTA and other chelating agents activate Homo sapiens
1.8.4.2 EDTA and other chelating agents activate Rattus norvegicus
1.8.4.2 EDTA and other chelating agents activate Bos taurus
1.8.4.2 additional information overview Mus musculus
1.8.4.2 additional information overview Homo sapiens
1.8.4.2 additional information overview Rattus norvegicus
1.8.4.2 additional information overview Bos taurus
1.8.4.2 phosphatidylethanolamine activates at low concentration Mus musculus
1.8.4.2 phosphatidylethanolamine activates at low concentration Homo sapiens
1.8.4.2 phosphatidylethanolamine activates at low concentration Rattus norvegicus
1.8.4.2 phosphatidylethanolamine activates at low concentration Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.2 Aprotinin
-
Bos taurus
1.8.4.2 Aprotinin
-
Homo sapiens
1.8.4.2 Aprotinin
-
Mus musculus
1.8.4.2 Aprotinin
-
Rattus norvegicus
1.8.4.2 bacitracin
-
Bos taurus
1.8.4.2 bacitracin
-
Homo sapiens
1.8.4.2 bacitracin
-
Mus musculus
1.8.4.2 bacitracin
-
Rattus norvegicus
1.8.4.2 Ca2+ slight Bos taurus
1.8.4.2 Ca2+ slight Homo sapiens
1.8.4.2 Ca2+ slight Mus musculus
1.8.4.2 Ca2+ slight Rattus norvegicus
1.8.4.2 Cu2+
-
Bos taurus
1.8.4.2 Cu2+
-
Homo sapiens
1.8.4.2 Cu2+
-
Mus musculus
1.8.4.2 Cu2+
-
Rattus norvegicus
1.8.4.2 Hg2+
-
Bos taurus
1.8.4.2 Hg2+
-
Homo sapiens
1.8.4.2 Hg2+
-
Mus musculus
1.8.4.2 Hg2+
-
Rattus norvegicus
1.8.4.2 lysolecithin
-
Bos taurus
1.8.4.2 lysolecithin
-
Homo sapiens
1.8.4.2 lysolecithin
-
Mus musculus
1.8.4.2 lysolecithin
-
Rattus norvegicus
1.8.4.2 additional information overview Bos taurus
1.8.4.2 additional information overview Homo sapiens
1.8.4.2 additional information overview Mus musculus
1.8.4.2 additional information overview Rattus norvegicus
1.8.4.2 Ni2+ slight Bos taurus
1.8.4.2 Ni2+ slight Homo sapiens
1.8.4.2 Ni2+ slight Mus musculus
1.8.4.2 Ni2+ slight Rattus norvegicus
1.8.4.2 phosphatidic acid
-
Bos taurus
1.8.4.2 phosphatidic acid
-
Homo sapiens
1.8.4.2 phosphatidic acid
-
Mus musculus
1.8.4.2 phosphatidic acid
-
Rattus norvegicus
1.8.4.2 Se2+
-
Bos taurus
1.8.4.2 Se2+
-
Homo sapiens
1.8.4.2 Se2+
-
Mus musculus
1.8.4.2 Se2+
-
Rattus norvegicus
1.8.4.2 Zn2+
-
Bos taurus
1.8.4.2 Zn2+
-
Homo sapiens
1.8.4.2 Zn2+
-
Mus musculus
1.8.4.2 Zn2+
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.4.2 additional information
-
additional information
-
Mus musculus
1.8.4.2 additional information
-
additional information
-
Homo sapiens
1.8.4.2 additional information
-
additional information
-
Rattus norvegicus
1.8.4.2 additional information
-
additional information
-
Bos taurus
1.8.4.2 0.01
-
Insulin
-
Mus musculus
1.8.4.2 0.01
-
Insulin
-
Homo sapiens
1.8.4.2 0.01
-
Insulin
-
Rattus norvegicus
1.8.4.2 0.01
-
Insulin
-
Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.2 endoplasmic reticulum
-
Rattus norvegicus 5783
-
1.8.4.2 membrane bound to Rattus norvegicus 16020
-
1.8.4.2 microsome majority of the enzyme located at Rattus norvegicus
-
-
1.8.4.2 microsome weakly bound on cisternal surface of microsomes via phospholipids Rattus norvegicus
-
-
1.8.4.2 secretory granule of alpha and beta cells of islets of Langerhans Rattus norvegicus 30141
-
1.8.4.2 zymogen granule of acinar cells Rattus norvegicus 42588
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.4.2 additional information
-
3 molecular forms: MW 56000 is the major form, MW 51000 is active and only present in spleen, possibly a proteolytic product of 56000 MW protein, MW 67000 is possibly a precursor of 56000 MW protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.2 GSH + protein disulfide Mus musculus physiological function GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Homo sapiens physiological function GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Rattus norvegicus physiological function GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Bos taurus physiological function GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Mus musculus reductive degradation and assembly of proteins GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Homo sapiens reductive degradation and assembly of proteins GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Rattus norvegicus reductive degradation and assembly of proteins GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Bos taurus reductive degradation and assembly of proteins GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Mus musculus modulation of enzymatic activity from latent to active form and vice versa GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Homo sapiens modulation of enzymatic activity from latent to active form and vice versa GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Rattus norvegicus modulation of enzymatic activity from latent to active form and vice versa GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Bos taurus modulation of enzymatic activity from latent to active form and vice versa GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Mus musculus feedback control via insulin in the liver GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Homo sapiens feedback control via insulin in the liver GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Rattus norvegicus feedback control via insulin in the liver GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide Bos taurus feedback control via insulin in the liver GSSG + protein-dithiol
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Bos taurus
-
-
-
1.8.4.2 Homo sapiens
-
-
-
1.8.4.2 Mus musculus
-
-
-
1.8.4.2 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.8.4.2 phospholipoprotein
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 adipose tissue
-
Rattus norvegicus
-
1.8.4.2 brain
-
Rattus norvegicus
-
1.8.4.2 diaphragm
-
Rattus norvegicus
-
1.8.4.2 erythrocyte
-
Homo sapiens
-
1.8.4.2 heart
-
Mus musculus
-
1.8.4.2 heart
-
Homo sapiens
-
1.8.4.2 heart
-
Rattus norvegicus
-
1.8.4.2 heart
-
Bos taurus
-
1.8.4.2 intestine
-
Rattus norvegicus
-
1.8.4.2 kidney
-
Mus musculus
-
1.8.4.2 kidney
-
Homo sapiens
-
1.8.4.2 kidney
-
Rattus norvegicus
-
1.8.4.2 kidney
-
Bos taurus
-
1.8.4.2 lens
-
Rattus norvegicus
-
1.8.4.2 leukocyte
-
Homo sapiens
-
1.8.4.2 liver
-
Mus musculus
-
1.8.4.2 liver
-
Homo sapiens
-
1.8.4.2 liver
-
Rattus norvegicus
-
1.8.4.2 liver
-
Bos taurus
-
1.8.4.2 lung
-
Homo sapiens
-
1.8.4.2 lung
-
Rattus norvegicus
-
1.8.4.2 additional information
-
Mus musculus
-
1.8.4.2 additional information
-
Rattus norvegicus
-
1.8.4.2 additional information
-
Bos taurus
-
1.8.4.2 additional information higher activity in mononuclear cells than in polymorphonuclear cells Homo sapiens
-
1.8.4.2 pancreas
-
Mus musculus
-
1.8.4.2 pancreas
-
Homo sapiens
-
1.8.4.2 pancreas
-
Rattus norvegicus
-
1.8.4.2 pancreas
-
Bos taurus
-
1.8.4.2 placenta
-
Rattus norvegicus
-
1.8.4.2 retina
-
Rattus norvegicus
-
1.8.4.2 skeletal muscle
-
Rattus norvegicus
-
1.8.4.2 spleen
-
Rattus norvegicus
-
1.8.4.2 testis
-
Rattus norvegicus
-
1.8.4.2 thymus
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.2 additional information
-
assay methods Mus musculus
1.8.4.2 additional information
-
assay methods Homo sapiens
1.8.4.2 additional information
-
assay methods Rattus norvegicus
1.8.4.2 additional information
-
assay methods Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 2,3-dimercaptopropanol + protein disulfide
-
Mus musculus 2,3-dimercaptopropanol disulfide + protein-dithiol
-
?
1.8.4.2 2,3-dimercaptopropanol + protein disulfide
-
Homo sapiens 2,3-dimercaptopropanol disulfide + protein-dithiol
-
?
1.8.4.2 2,3-dimercaptopropanol + protein disulfide
-
Rattus norvegicus 2,3-dimercaptopropanol disulfide + protein-dithiol
-
?
1.8.4.2 2,3-dimercaptopropanol + protein disulfide
-
Bos taurus 2,3-dimercaptopropanol disulfide + protein-dithiol
-
?
1.8.4.2 cysteamine + protein disulfide
-
Mus musculus ?
-
?
1.8.4.2 cysteamine + protein disulfide
-
Homo sapiens ?
-
?
1.8.4.2 cysteamine + protein disulfide
-
Rattus norvegicus ?
-
?
1.8.4.2 cysteamine + protein disulfide
-
Bos taurus ?
-
?
1.8.4.2 dihydrolipoic acid + protein disulfide
-
Mus musculus ?
-
?
1.8.4.2 dihydrolipoic acid + protein disulfide
-
Homo sapiens ?
-
?
1.8.4.2 dihydrolipoic acid + protein disulfide
-
Rattus norvegicus ?
-
?
1.8.4.2 dihydrolipoic acid + protein disulfide
-
Bos taurus ?
-
?
1.8.4.2 GSH + insulin proinsulin Mus musculus GSSG + reduced insulin chain A and B
-
?
1.8.4.2 GSH + insulin proinsulin Homo sapiens GSSG + reduced insulin chain A and B
-
?
1.8.4.2 GSH + insulin proinsulin Rattus norvegicus GSSG + reduced insulin chain A and B
-
?
1.8.4.2 GSH + insulin proinsulin Bos taurus GSSG + reduced insulin chain A and B
-
?
1.8.4.2 GSH + oxytoxin
-
Mus musculus ?
-
?
1.8.4.2 GSH + oxytoxin
-
Homo sapiens ?
-
?
1.8.4.2 GSH + oxytoxin
-
Rattus norvegicus ?
-
?
1.8.4.2 GSH + oxytoxin
-
Bos taurus ?
-
?
1.8.4.2 GSH + protein disulfide
-
Mus musculus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide
-
Homo sapiens GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide
-
Rattus norvegicus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide
-
Bos taurus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide physiological function Mus musculus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide physiological function Homo sapiens GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide physiological function Rattus norvegicus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide physiological function Bos taurus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide reductive degradation and assembly of proteins Mus musculus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide reductive degradation and assembly of proteins Homo sapiens GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide reductive degradation and assembly of proteins Rattus norvegicus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide reductive degradation and assembly of proteins Bos taurus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide modulation of enzymatic activity from latent to active form and vice versa Mus musculus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide modulation of enzymatic activity from latent to active form and vice versa Homo sapiens GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide modulation of enzymatic activity from latent to active form and vice versa Rattus norvegicus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide modulation of enzymatic activity from latent to active form and vice versa Bos taurus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide feedback control via insulin in the liver Mus musculus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide feedback control via insulin in the liver Homo sapiens GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide feedback control via insulin in the liver Rattus norvegicus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + protein disulfide feedback control via insulin in the liver Bos taurus GSSG + protein-dithiol
-
?
1.8.4.2 GSH + vasopressin
-
Mus musculus ?
-
?
1.8.4.2 GSH + vasopressin
-
Homo sapiens ?
-
?
1.8.4.2 GSH + vasopressin
-
Rattus norvegicus ?
-
?
1.8.4.2 GSH + vasopressin
-
Bos taurus ?
-
?
1.8.4.2 additional information the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Mus musculus ?
-
?
1.8.4.2 additional information the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Homo sapiens ?
-
?
1.8.4.2 additional information the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Rattus norvegicus ?
-
?
1.8.4.2 additional information the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Bos taurus ?
-
?
1.8.4.2 additional information immunoglobulin IgM and IgG Mus musculus ?
-
?
1.8.4.2 additional information immunoglobulin IgM and IgG Homo sapiens ?
-
?
1.8.4.2 additional information immunoglobulin IgM and IgG Rattus norvegicus ?
-
?
1.8.4.2 additional information immunoglobulin IgM and IgG Bos taurus ?
-
?
1.8.4.2 additional information scrambled lysozyme Mus musculus ?
-
?
1.8.4.2 additional information scrambled lysozyme Homo sapiens ?
-
?
1.8.4.2 additional information scrambled lysozyme Rattus norvegicus ?
-
?
1.8.4.2 additional information scrambled lysozyme Bos taurus ?
-
?
1.8.4.2 additional information thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Mus musculus ?
-
?
1.8.4.2 additional information thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Homo sapiens ?
-
?
1.8.4.2 additional information thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Rattus norvegicus ?
-
?
1.8.4.2 additional information thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Bos taurus ?
-
?
1.8.4.2 additional information enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease Mus musculus ?
-
?
1.8.4.2 additional information enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease Homo sapiens ?
-
?
1.8.4.2 additional information enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease Rattus norvegicus ?
-
?
1.8.4.2 additional information enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease Bos taurus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.2 GIT
-
Mus musculus
1.8.4.2 GIT
-
Homo sapiens
1.8.4.2 GIT
-
Rattus norvegicus
1.8.4.2 GIT
-
Bos taurus
1.8.4.2 More the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Mus musculus
1.8.4.2 More the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Homo sapiens
1.8.4.2 More the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Rattus norvegicus
1.8.4.2 More the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme Bos taurus
1.8.4.2 More thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Mus musculus
1.8.4.2 More thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Homo sapiens
1.8.4.2 More thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Rattus norvegicus
1.8.4.2 More thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical Bos taurus