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Literature summary extracted from

  • Carlberg, I.; Mannervik, B.
    Purification and characterization of the flavoenzyme glutathione reductase from rat liver (1975), J. Biol. Chem., 250, 5475-5480.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 NADP+
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.7 60000
-
 2 * 60000, SDS-PAGE Rattus norvegicus
1.8.1.7 125000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.7
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.1.7 207
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 GSSG + NADPH
-
 Rattus norvegicus glutathione + NADP+
-
 ?
1.8.1.7 additional information branched mechanism Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.1.7 dimer 2 * 60000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.7 5 5.5 NADH + GSSG Rattus norvegicus
1.8.1.7 7
-
 NADPH + GSSG Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD 2 mol of FAD per mol of enzyme Rattus norvegicus
1.8.1.7 additional information no activity with FMN Rattus norvegicus
1.8.1.7 NADH 10% activity of that with NADPH Rattus norvegicus