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Literature summary extracted from
- Glutathione reductase from human erythrocytes. Catalytic properties and aggregation (1976), Eur. J. Biochem., 67, 231-238.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | KCl | - |
Homo sapiens |  |
| 1.8.1.7 | Sodium phosphate | - |
Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | glutathione | - |
Homo sapiens | |
| 1.8.1.7 | NADH | - |
Homo sapiens | |
| 1.8.1.7 | NADP+ | competitive against NADPH | Homo sapiens | |
| 1.8.1.7 | NADPH | promotes formation of aggregates, reversible by thiols, e.g. glutathione or 2-mercaptoethanol | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 0.008 | - |
NADPH | - |
Homo sapiens | |
| 1.8.1.7 | 0.065 | - |
GSSG | - |
Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 100000 | - |
- |
Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Homo sapiens | - |
- |
- |
Oxidation Stability
| EC Number | Oxidation Stability | Organism |
|---|---|---|
| 1.8.1.7 | oxygen promotes enzyme aggregation by oxidation of thiols, that prevent oxidation of the enzyme | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 250 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | GSSG + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | dimer | - |
Homo sapiens |
| 1.8.1.7 | More | NADH promotes aggregation | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 210 | - |
GSSG | - |
Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 5.7 | - |
NADH + GSSG | Homo sapiens |
| 1.8.1.7 | 6.8 | - |
NADPH + GSSG | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | NADH | - |
Homo sapiens | |
| 1.8.1.7 | NADPH | NADPH promoted aggregation of the enzyme | Homo sapiens | |
| 1.8.1.7 | NADPH | best electron donor | Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 0.07 | - |
NADP+ | - |
Homo sapiens | |
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