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Literature summary extracted from

  • Wong, K.K.; Vanoni, M.A.; Blanchard, J.S.
    Glutathione reductase: solvent equilibrium and kinetic isotope effects (1988), Biochemistry, 27, 7091-7096.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.7 additional information
-
 additional information
-
 Homo sapiens
1.8.1.7 additional information
-
 additional information
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-
1.8.1.7 Saccharomyces cerevisiae
-
 baker's yeast
-
1.8.1.7 Spinacia oleracea
-
 spinach
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.1.7 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ ping-pong mechanism Homo sapiens
a
1.8.1.7 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ ping-pong mechanism Saccharomyces cerevisiae
a
1.8.1.7 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ ping-pong mechanism Spinacia oleracea
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 GSSG + NADPH
-
 Homo sapiens glutathione + NADP+
-
 ?
1.8.1.7 GSSG + NADPH
-
 Saccharomyces cerevisiae glutathione + NADP+
-
 ?
1.8.1.7 GSSG + NADPH
-
 Spinacia oleracea glutathione + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.1.7 25
-
 assay at Homo sapiens
1.8.1.7 25
-
 assay at Saccharomyces cerevisiae
1.8.1.7 25
-
 assay at Spinacia oleracea

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.7 7.8 8.6 broad optimum Homo sapiens
1.8.1.7 7.8 8.6 broad optimum Saccharomyces cerevisiae
1.8.1.7 7.8 8.6 broad optimum Spinacia oleracea

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.8.1.7 6.6 10.8 at saturating NADPH levels Homo sapiens
1.8.1.7 6.6 10.8 at saturating NADPH levels Saccharomyces cerevisiae
1.8.1.7 6.6 10.8 at saturating NADPH levels Spinacia oleracea

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 NADPH
-
 Homo sapiens
1.8.1.7 NADPH
-
 Saccharomyces cerevisiae
1.8.1.7 NADPH
-
 Spinacia oleracea