Any feedback?
Literature summary extracted from
- Glutathione reductase (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 553-596.
No PubMed abstract available
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.8.1.7 | molecular asymmetry of crystals from deionized water and from 2 M ammonium sulfate, exact 2fold molecular axis in the dimer, form A-D, three-dimensional structure | Homo sapiens |
| 1.8.1.7 | trigonal crystals, high internal symmetry | Escherichia coli |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.8.1.7 | concentrated solution, stable for years | Mus musculus |
| 1.8.1.7 | concentrated solution, stable for years | Escherichia coli |
| 1.8.1.7 | concentrated solution, stable for years | Homo sapiens |
| 1.8.1.7 | concentrated solution, stable for years | Rattus norvegicus |
| 1.8.1.7 | concentrated solution, stable for years | Sus scrofa |
| 1.8.1.7 | concentrated solution, stable for years | Saccharomyces cerevisiae |
| 1.8.1.7 | concentrated solution, stable for years | Bos taurus |
| 1.8.1.7 | concentrated solution, stable for years | Oryctolagus cuniculus |
| 1.8.1.7 | concentrated solution, stable for years | Penicillium chrysogenum |
| 1.8.1.7 | concentrated solution, stable for years | Spinacia oleracea |
| 1.8.1.7 | concentrated solution, stable for years | Meriones unguiculatus |
| 1.8.1.7 | concentrated solution, stable for years | Allochromatium vinosum |
| 1.8.1.7 | concentrated solution, stable for years | Scombridae |
| 1.8.1.7 | concentrated solution, stable for years | Plasmodium vinckei |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Mus musculus |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Escherichia coli |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Homo sapiens |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Rattus norvegicus |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Sus scrofa |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Saccharomyces cerevisiae |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Bos taurus |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Oryctolagus cuniculus |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Penicillium chrysogenum |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Spinacia oleracea |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Meriones unguiculatus |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Allochromatium vinosum |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Scombridae |
| 1.8.1.7 | crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable | Plasmodium vinckei |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Mus musculus |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Escherichia coli |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Homo sapiens |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Rattus norvegicus |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Sus scrofa |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Saccharomyces cerevisiae |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Bos taurus |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Oryctolagus cuniculus |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Penicillium chrysogenum |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Spinacia oleracea |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Meriones unguiculatus |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Allochromatium vinosum |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Scombridae |
| 1.8.1.7 | repeated freezing and thawing, inactivation | Plasmodium vinckei |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | 1,2-Cyclohexanedione | - |
Homo sapiens |  |
| 1.8.1.7 | 1,3-Bis-(2-chloroethyl)-1-nitrosourea | - |
Homo sapiens | |
| 1.8.1.7 | 1,3-Bis-(2-chloroethyl)-1-nitrosourea | - |
Rattus norvegicus | |
| 1.8.1.7 | 1,3-Bis-(2-chloroethyl)-1-nitrosourea | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | 1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea | - |
Homo sapiens | |
| 1.8.1.7 | 1-chloro-2,4-dinitrobenzene | reversible | Homo sapiens | |
| 1.8.1.7 | 1-Fluoro-2,4-dinitrobenzene | reversible | Saccharomyces cerevisiae | |
| 1.8.1.7 | 2,3-Butanedione | - |
Homo sapiens | |
| 1.8.1.7 | 2,4,6-Trinitrobenzenesulfonate | reversible | Bos taurus | |
| 1.8.1.7 | 2-Chloroethylisocyanate | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | arsenite | - |
Homo sapiens | |
| 1.8.1.7 | arsenite | - |
Litomosoides carinii | |
| 1.8.1.7 | arsenite | - |
Rattus norvegicus | |
| 1.8.1.7 | arsenite | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | Benzylselenosulfate | - |
Rattus norvegicus | |
| 1.8.1.7 | Cd2+ | - |
Homo sapiens | |
| 1.8.1.7 | Cd2+ | - |
Scombridae | |
| 1.8.1.7 | chromate | - |
Allochromatium vinosum | |
| 1.8.1.7 | chromate | - |
Bos taurus | |
| 1.8.1.7 | chromate | - |
Escherichia coli | |
| 1.8.1.7 | chromate | - |
Homo sapiens | |
| 1.8.1.7 | chromate | - |
Meriones unguiculatus | |
| 1.8.1.7 | chromate | - |
Mus musculus | |
| 1.8.1.7 | chromate | - |
Oryctolagus cuniculus | |
| 1.8.1.7 | chromate | - |
Penicillium chrysogenum | |
| 1.8.1.7 | chromate | - |
Plasmodium vinckei | |
| 1.8.1.7 | chromate | probably irreversible | Rattus norvegicus | |
| 1.8.1.7 | chromate | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | chromate | - |
Scombridae | |
| 1.8.1.7 | chromate | - |
Spinacia oleracea | |
| 1.8.1.7 | chromate | - |
Sus scrofa | |
| 1.8.1.7 | Cu2+ | - |
Allochromatium vinosum | |
| 1.8.1.7 | Cu2+ | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | dinitrosated isomers of N,N'-bis[N(2-chloroethyl)-N-carbonyl]cysteamine | - |
Rattus norvegicus | |
| 1.8.1.7 | Haemin | mediates covalent cross-linking and degradation of the enzyme | Saccharomyces cerevisiae | |
| 1.8.1.7 | Hg2+ | - |
Rattus norvegicus | |
| 1.8.1.7 | Iodine | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | iodoacetamide | - |
Homo sapiens | |
| 1.8.1.7 | iodoacetamide | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | Melarsen oxide | - |
Homo sapiens | |
| 1.8.1.7 | Melarsen oxide | - |
Litomosoides carinii | |
| 1.8.1.7 | additional information | regulation by inactivation in vivo, e.g. by disulfide bridging | Homo sapiens | |
| 1.8.1.7 | additional information | regulation by inactivation in vivo, e.g. by disulfide bridging | Mus musculus | |
| 1.8.1.7 | additional information | regulation by inactivation in vivo, e.g. by disulfide bridging | Saccharomyces cerevisiae | |
| 1.8.1.7 | N,N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea | - |
Rattus norvegicus | |
| 1.8.1.7 | N-Alkylmaleimide | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | nifurtimox | - |
Homo sapiens | |
| 1.8.1.7 | nifurtimox | - |
Rattus norvegicus | |
| 1.8.1.7 | Nitrofurantoin | - |
Allochromatium vinosum | |
| 1.8.1.7 | Nitrofurantoin | - |
Bos taurus | |
| 1.8.1.7 | Nitrofurantoin | - |
Escherichia coli | |
| 1.8.1.7 | Nitrofurantoin | - |
Homo sapiens | |
| 1.8.1.7 | Nitrofurantoin | - |
Meriones unguiculatus | |
| 1.8.1.7 | Nitrofurantoin | - |
Mus musculus | |
| 1.8.1.7 | Nitrofurantoin | - |
Oryctolagus cuniculus | |
| 1.8.1.7 | Nitrofurantoin | - |
Penicillium chrysogenum | |
| 1.8.1.7 | Nitrofurantoin | - |
Plasmodium vinckei | |
| 1.8.1.7 | Nitrofurantoin | - |
Rattus norvegicus | |
| 1.8.1.7 | Nitrofurantoin | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | Nitrofurantoin | - |
Scombridae | |
| 1.8.1.7 | Nitrofurantoin | - |
Spinacia oleracea | |
| 1.8.1.7 | Nitrofurantoin | - |
Sus scrofa | |
| 1.8.1.7 | Nitrogen mustard | - |
Homo sapiens | |
| 1.8.1.7 | p-hydroxymercuribenzoate | - |
Allochromatium vinosum | |
| 1.8.1.7 | p-hydroxymercuribenzoate | - |
Escherichia coli | |
| 1.8.1.7 | p-hydroxymercuribenzoate | - |
Meriones unguiculatus | |
| 1.8.1.7 | p-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
| 1.8.1.7 | p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| 1.8.1.7 | Phenylarsonous acid | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | Phenylglyoxal | - |
Homo sapiens | |
| 1.8.1.7 | Phenylglyoxal | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | S-(2,4-dinitrophenyl)-glutathione | - |
Homo sapiens | |
| 1.8.1.7 | Zn2+ | - |
Homo sapiens | |
| 1.8.1.7 | Zn2+ | - |
Rattus norvegicus | |
| 1.8.1.7 | Zn2+ | - |
Spinacia oleracea | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 0.008 | - |
NADPH | - |
Homo sapiens | |
| 1.8.1.7 | 0.008 | - |
NADPH | - |
Rattus norvegicus | |
| 1.8.1.7 | 0.008 | - |
NADPH | - |
Oryctolagus cuniculus | |
| 1.8.1.7 | 0.065 | - |
GSSG | - |
Homo sapiens | |
| 1.8.1.7 | 0.25 | - |
glutathione-S-sulfonate | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | 1 | - |
mixed disulfide of coenzyme A and glutathione | - |
Homo sapiens | |
| 1.8.1.7 | 7 | - |
GSSG | - |
Allochromatium vinosum | |
| 1.8.1.7 | 11.6 | - |
bis-N,N'-(gamma-glutamylcystine) | - |
Saccharomyces cerevisiae | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.7 | chloroplast | cytoplasm-like spaces of chloroplasts | Spinacia oleracea | 9507 | - |
| 1.8.1.7 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
| 1.8.1.7 | cytoplasm | - |
Bos taurus | 5737 | - |
| 1.8.1.7 | mitochondrion | cytoplasm-like spaces of mitochondria | Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 52500 | - |
2 * 52500 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | GSSG + NADPH | Rattus norvegicus | - |
glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Mus musculus | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Escherichia coli | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Homo sapiens | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Sus scrofa | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Saccharomyces cerevisiae | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Bos taurus | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Oryctolagus cuniculus | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Penicillium chrysogenum | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Spinacia oleracea | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Meriones unguiculatus | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Allochromatium vinosum | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Scombridae | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Plasmodium vinckei | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | Bufo bufo | high GSSG level in dormant stage | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | additional information | Homo sapiens | glutathione redox cycle | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Allochromatium vinosum | - |
- |
- |
| 1.8.1.7 | Bos taurus | - |
- |
- |
| 1.8.1.7 | Bufo bufo | - |
toad | - |
| 1.8.1.7 | Escherichia coli | - |
- |
- |
| 1.8.1.7 | Homo sapiens | - |
- |
- |
| 1.8.1.7 | Litomosoides carinii | - |
- |
- |
| 1.8.1.7 | Meriones unguiculatus | - |
- |
- |
| 1.8.1.7 | Mus musculus | - |
- |
- |
| 1.8.1.7 | Oryctolagus cuniculus | - |
- |
- |
| 1.8.1.7 | Penicillium chrysogenum | - |
- |
- |
| 1.8.1.7 | Plasmodium vinckei | - |
- |
- |
| 1.8.1.7 | Rattus norvegicus | - |
- |
- |
| 1.8.1.7 | Saccharomyces cerevisiae | - |
baker's yeast | - |
| 1.8.1.7 | Scombridae | - |
- |
- |
| 1.8.1.7 | Spinacia oleracea | - |
spinach | - |
| 1.8.1.7 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.1.7 | partially | Litomosoides carinii |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | mechanism | Escherichia coli | |
| 1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | mechanism | Homo sapiens | |
| 1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | mechanism | Rattus norvegicus | |
| 1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | mechanism | Saccharomyces cerevisiae | |
| 1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | mechanism | Penicillium chrysogenum | |
| 1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | GSSG-binding site | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | erythrocyte | - |
Homo sapiens | - |
| 1.8.1.7 | erythrocyte | - |
Sus scrofa | - |
| 1.8.1.7 | erythrocyte | - |
Oryctolagus cuniculus | - |
| 1.8.1.7 | leaf | - |
Spinacia oleracea | - |
| 1.8.1.7 | lens fiber | - |
Homo sapiens | - |
| 1.8.1.7 | leukocyte | - |
Homo sapiens | - |
| 1.8.1.7 | liver | - |
Mus musculus | - |
| 1.8.1.7 | liver | - |
Rattus norvegicus | - |
| 1.8.1.7 | liver | - |
Bos taurus | - |
| 1.8.1.7 | liver | - |
Oryctolagus cuniculus | - |
| 1.8.1.7 | liver | - |
Meriones unguiculatus | - |
| 1.8.1.7 | muscle | - |
Scombridae | - |
| 1.8.1.7 | platelet | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | additional information | - |
- |
Escherichia coli |
| 1.8.1.7 | additional information | - |
- |
Bos taurus |
| 1.8.1.7 | additional information | - |
activity decreases with age of the organism | Mus musculus |
| 1.8.1.7 | additional information | - |
activity decreases with age of the organism | Homo sapiens |
| 1.8.1.7 | additional information | - |
activity decreases with age of the organism | Rattus norvegicus |
| 1.8.1.7 | 240 | - |
- |
Homo sapiens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Mus musculus |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Escherichia coli |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Homo sapiens |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Rattus norvegicus |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Sus scrofa |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Saccharomyces cerevisiae |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Bos taurus |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Oryctolagus cuniculus |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Penicillium chrysogenum |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Spinacia oleracea |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Meriones unguiculatus |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Allochromatium vinosum |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Scombridae |
| 1.8.1.7 | 4°C, activation after storage over days, months or years | Plasmodium vinckei |
| 1.8.1.7 | concentrated solution, years | Mus musculus |
| 1.8.1.7 | concentrated solution, years | Escherichia coli |
| 1.8.1.7 | concentrated solution, years | Homo sapiens |
| 1.8.1.7 | concentrated solution, years | Rattus norvegicus |
| 1.8.1.7 | concentrated solution, years | Sus scrofa |
| 1.8.1.7 | concentrated solution, years | Saccharomyces cerevisiae |
| 1.8.1.7 | concentrated solution, years | Bos taurus |
| 1.8.1.7 | concentrated solution, years | Oryctolagus cuniculus |
| 1.8.1.7 | concentrated solution, years | Penicillium chrysogenum |
| 1.8.1.7 | concentrated solution, years | Spinacia oleracea |
| 1.8.1.7 | concentrated solution, years | Meriones unguiculatus |
| 1.8.1.7 | concentrated solution, years | Allochromatium vinosum |
| 1.8.1.7 | concentrated solution, years | Scombridae |
| 1.8.1.7 | concentrated solution, years | Plasmodium vinckei |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | bis-N,N'-(gamma-glutamylcystine) + NADPH + H+ | - |
Saccharomyces cerevisiae | ? | - |
r | |
| 1.8.1.7 | glutathione + NADP+ | mixed disulfide of CoA and glutathione | Homo sapiens | glutathione disulfide + NADPH + H+ | - |
r | |
| 1.8.1.7 | glutathione-S-sulfonate + NADPH + H+ | - |
Saccharomyces cerevisiae | ? | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Mus musculus | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Rattus norvegicus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Sus scrofa | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Sus scrofa | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Bos taurus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Bos taurus | glutathione + NADP+ | - |
ir | |
| 1.8.1.7 | GSSG + NADPH | - |
Bos taurus | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Oryctolagus cuniculus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Oryctolagus cuniculus | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Spinacia oleracea | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Spinacia oleracea | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Meriones unguiculatus | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Allochromatium vinosum | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Scombridae | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Plasmodium vinckei | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Litomosoides carinii | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Litomosoides carinii | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | - |
Bufo bufo | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Escherichia coli | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Escherichia coli | glutathione + NADP+ | - |
ir | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Escherichia coli | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Rattus norvegicus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Rattus norvegicus | glutathione + NADP+ | - |
ir | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Rattus norvegicus | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Saccharomyces cerevisiae | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Saccharomyces cerevisiae | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Penicillium chrysogenum | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine | Penicillium chrysogenum | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | slight activity with D,L-lipoate | Homo sapiens | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | slight activity with D,L-lipoate | Homo sapiens | glutathione + NADP+ | - |
ir | |
| 1.8.1.7 | GSSG + NADPH | slight activity with D,L-lipoate | Homo sapiens | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Homo sapiens | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Homo sapiens | glutathione + NADP+ | - |
ir | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Homo sapiens | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Rattus norvegicus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Rattus norvegicus | glutathione + NADP+ | - |
ir | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Rattus norvegicus | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Saccharomyces cerevisiae | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | mixed disulfide between coenzyme A and glutathione | Saccharomyces cerevisiae | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | slight activity with bis-N,N'-(gamma-glutamylcystine) | Saccharomyces cerevisiae | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | slight activity with bis-N,N'-(gamma-glutamylcystine) | Saccharomyces cerevisiae | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | glutathione-S-sulfonate | Saccharomyces cerevisiae | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | glutathione-S-sulfonate | Saccharomyces cerevisiae | glutathione + NADP+ | - |
r | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Mus musculus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Escherichia coli | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Homo sapiens | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Sus scrofa | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Saccharomyces cerevisiae | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Bos taurus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Oryctolagus cuniculus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Penicillium chrysogenum | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Spinacia oleracea | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Meriones unguiculatus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Allochromatium vinosum | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Scombridae | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen | Plasmodium vinckei | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | high GSSG level in dormant stage | Bufo bufo | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | additional information | - |
Mus musculus | ? | - |
? | |
| 1.8.1.7 | additional information | - |
Rattus norvegicus | ? | - |
? | |
| 1.8.1.7 | additional information | - |
Sus scrofa | ? | - |
? | |
| 1.8.1.7 | additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
| 1.8.1.7 | additional information | - |
Spinacia oleracea | ? | - |
? | |
| 1.8.1.7 | additional information | - |
Meriones unguiculatus | ? | - |
? | |
| 1.8.1.7 | additional information | - |
Allochromatium vinosum | ? | - |
? | |
| 1.8.1.7 | additional information | glutathione redox cycle | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | dimer | - |
Mus musculus |
| 1.8.1.7 | dimer | - |
Escherichia coli |
| 1.8.1.7 | dimer | - |
Rattus norvegicus |
| 1.8.1.7 | dimer | - |
Sus scrofa |
| 1.8.1.7 | dimer | - |
Bos taurus |
| 1.8.1.7 | dimer | - |
Oryctolagus cuniculus |
| 1.8.1.7 | dimer | - |
Spinacia oleracea |
| 1.8.1.7 | dimer | - |
Meriones unguiculatus |
| 1.8.1.7 | dimer | 2 * 52500 | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 210 | - |
GSSG | - |
Homo sapiens | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | FAD | FAD enzyme | Mus musculus | |
| 1.8.1.7 | FAD | FAD enzyme | Escherichia coli | |
| 1.8.1.7 | FAD | FAD enzyme | Homo sapiens | |
| 1.8.1.7 | FAD | FAD enzyme | Rattus norvegicus | |
| 1.8.1.7 | FAD | FAD enzyme | Sus scrofa | |
| 1.8.1.7 | FAD | FAD enzyme | Saccharomyces cerevisiae | |
| 1.8.1.7 | FAD | FAD enzyme | Bos taurus | |
| 1.8.1.7 | FAD | FAD enzyme | Oryctolagus cuniculus | |
| 1.8.1.7 | FAD | FAD enzyme | Penicillium chrysogenum | |
| 1.8.1.7 | FAD | FAD enzyme | Spinacia oleracea | |
| 1.8.1.7 | FAD | FAD enzyme | Meriones unguiculatus | |
| 1.8.1.7 | FAD | FAD enzyme | Allochromatium vinosum | |
| 1.8.1.7 | FAD | FAD enzyme | Scombridae | |
| 1.8.1.7 | FAD | FAD enzyme | Plasmodium vinckei | |
| 1.8.1.7 | flavin | flavoprotein | Mus musculus | |
| 1.8.1.7 | flavin | flavoprotein | Escherichia coli | |
| 1.8.1.7 | flavin | flavoprotein | Homo sapiens | |
| 1.8.1.7 | flavin | flavoprotein | Rattus norvegicus | |
| 1.8.1.7 | flavin | flavoprotein | Sus scrofa | |
| 1.8.1.7 | flavin | flavoprotein | Saccharomyces cerevisiae | |
| 1.8.1.7 | flavin | flavoprotein | Bos taurus | |
| 1.8.1.7 | flavin | flavoprotein | Oryctolagus cuniculus | |
| 1.8.1.7 | flavin | flavoprotein | Penicillium chrysogenum | |
| 1.8.1.7 | flavin | flavoprotein | Spinacia oleracea | |
| 1.8.1.7 | flavin | flavoprotein | Meriones unguiculatus | |
| 1.8.1.7 | flavin | flavoprotein | Allochromatium vinosum | |
| 1.8.1.7 | flavin | flavoprotein | Scombridae | |
| 1.8.1.7 | flavin | flavoprotein | Plasmodium vinckei | |
| 1.8.1.7 | NADH | - |
Rattus norvegicus | |
| 1.8.1.7 | NADH | - |
Sus scrofa | |
| 1.8.1.7 | NADH | - |
Spinacia oleracea | |
| 1.8.1.7 | NADH | - |
Allochromatium vinosum | |
| 1.8.1.7 | NADH | 20times less activity than with NADPH | Homo sapiens | |
| 1.8.1.7 | NADPH | - |
Mus musculus | |
| 1.8.1.7 | NADPH | - |
Escherichia coli | |
| 1.8.1.7 | NADPH | - |
Rattus norvegicus | |
| 1.8.1.7 | NADPH | - |
Sus scrofa | |
| 1.8.1.7 | NADPH | - |
Saccharomyces cerevisiae | |
| 1.8.1.7 | NADPH | - |
Bos taurus | |
| 1.8.1.7 | NADPH | - |
Oryctolagus cuniculus | |
| 1.8.1.7 | NADPH | - |
Penicillium chrysogenum | |
| 1.8.1.7 | NADPH | - |
Spinacia oleracea | |
| 1.8.1.7 | NADPH | - |
Meriones unguiculatus | |
| 1.8.1.7 | NADPH | - |
Scombridae | |
| 1.8.1.7 | NADPH | - |
Plasmodium vinckei | |
| 1.8.1.7 | NADPH | - |
Litomosoides carinii | |
| 1.8.1.7 | NADPH | - |
Bufo bufo | |
| 1.8.1.7 | NADPH | 20times more activity than with NADH | Homo sapiens | |
| 1.8.1.7 | NADPH | can utilize both NADPH and NADH, more active with NADPH | Homo sapiens | |
| 1.8.1.7 | NADPH | can utilize both NADPH and NADH, more active with NADPH | Allochromatium vinosum | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 0.00033 | - |
Hg2+ | - |
Rattus norvegicus | |
| 1.8.1.7 | 0.0005 | - |
2,4,6-trinitrobenzene-sulfonate | below, at 50% inhibition value, leading to oxidase activity | Bos taurus | |
| 1.8.1.7 | 0.0008 | - |
Zn2+ | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.001 | - |
Cu2+ | at 50% inhibition value | Saccharomyces cerevisiae | |
| 1.8.1.7 | 0.001 | - |
Cd2+ | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.001 | - |
Nitrofurantoin | at 50% inhibition value, enzyme partially purified from platelets | Homo sapiens | |
| 1.8.1.7 | 0.005 | - |
Zn2+ | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.0065 | - |
Zn2+ | at 50% inhibition value | Rattus norvegicus | |
| 1.8.1.7 | 0.0091 | - |
Melarsen oxide | at 50% inhibition value | Litomosoides carinii | |
| 1.8.1.7 | 0.01 | - |
p-hydroxymercuribenzoate | - |
Escherichia coli | |
| 1.8.1.7 | 0.02 | - |
Nitrofurantoin | at 50% inhibition value | Rattus norvegicus | |
| 1.8.1.7 | 0.022 | - |
1-chloro-2,4-dinitrobenzene | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.025 | - |
Nitrofurantoin | at 50% inhibition value, enzyme from erythrocytes | Homo sapiens | |
| 1.8.1.7 | 0.03 | - |
nifurtimox | at 50% inhibition value | Rattus norvegicus | |
| 1.8.1.7 | 0.03 | - |
S-(2,4-dinitrophenyl)-glutathione | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.04 | - |
nifurtimox | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.25 | - |
Cd2+ | - |
Scombridae | |
| 1.8.1.7 | 0.25 | - |
Melarsen oxide | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 0.35 | - |
chromate | - |
Rattus norvegicus | |
| 1.8.1.7 | 0.35 | - |
chromate | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 1.1 | - |
Nitrogen mustard | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 2.2 | 9 | arsenite | at 50% inhibition value | Homo sapiens | |
| 1.8.1.7 | 3 | - |
arsenite | at 50% inhibition value | Litomosoides carinii | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
