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Literature summary extracted from

  • Nandigama, R.K.; Miller, J.R.; Edmondson, D.E.
    Loss of serotonin oxidation as a component of the altered substrate specificity in the Y444F mutant of recombinant human liver MAO A (2001), Biochemistry, 40, 14839-14846.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 expression in Saccharomyces cerevisiae Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.4 Y407F Km for kynuramine not altered, higher Km for benzylamine analogue Homo sapiens
1.4.3.4 Y444F mutation alters the substrate specificity, that depends on the size of the aromatic ring and on the length of the alkyl side chain of various substrate analogues Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 amphetamine
-
 Homo sapiens
1.4.3.4 Clorgyline
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information comparison of MAO-A mutants using kynuramine, benzylamine and para-substituted benzylamine analogues as substrates Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.4 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 2-phenylethylamine + H2O + O2
-
 Homo sapiens 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + H2O + O2 analogs Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 dopamine + H2O + O2
-
 Homo sapiens (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2
-
 Homo sapiens RCHO + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 More MAO is a novel type of disulfide oxidoreductase Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information turnover number of MAO-A mutants Homo sapiens