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Literature summary extracted from

  • Erwin, V.G.; Hellerman, L.
    Mitochondrial monoamine oxidase. I. Purification and characterization of the bovine kidney enzyme (1967), J. Biol. Chem., 242, 4230-4238.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 1,10 phenanthroline weak inhibition Bos taurus
1.4.3.4 2-hydroxyquinoline reversible by dialysis Bos taurus
1.4.3.4 4-Cyanophenol weak inhibition Bos taurus
1.4.3.4 8-hydroxyquinoline reversible by the addition of Zn2+, Ni2+, Co2+ Bos taurus
1.4.3.4 alpha-Naphthol reversible by dialysis Bos taurus
1.4.3.4 beta-naphthol reversible by dialysis Bos taurus
1.4.3.4 Sodium diethyldithiocarbamate weak inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.07
-
 kynuramine
-
 Bos taurus
1.4.3.4 0.12
-
 benzylamine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.4 Cu2+ 0.00014-0.00015 mg copper per mg of protein, nonessential for activity Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.4
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 kidney
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.4 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 benzylamine + H2O + O2
-
 Bos taurus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2
-
 Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 specificity Bos taurus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 no activity with histamine Bos taurus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 oxidizes primary, secondary and tertiary amines Bos taurus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 5-hydroxytryptamine, MAO-A selective substrate Bos taurus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 tryptamine + H2O + O2
-
 Bos taurus 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2
-
 Bos taurus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 8.5
-
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 flavin 1 mol of flavin: per 100000 g of protein Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.1
-
 beta-naphthol
-
 Bos taurus
1.4.3.4 0.2
-
 alpha-Naphthol
-
 Bos taurus
1.4.3.4 0.25
-
 2-hydroxyquinoline
-
 Bos taurus
1.4.3.4 0.65
-
 8-hydroxyquinoline
-
 Bos taurus