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Literature summary extracted from
- Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases (1989), Arch. Biochem. Biophys., 268, 409-425.
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.4 | 49690 | - |
x * 49690, calculation from nucleotide sequence | Sus scrofa |
| 1.8.1.4 | 51274 | - |
x * 51274, calculation from nucleotide sequence | Escherichia coli |
| 1.8.1.4 | 54000 | - |
x * 54000, SDS-PAGE | Geobacillus stearothermophilus |
| 1.8.1.4 | 54000 | - |
x * 54000, SDS-PAGE | Ascaris suum |
| 1.8.1.4 | 55000 | - |
x * 55000, SDS-PAGE | Bos taurus |
| 1.8.1.4 | 56000 | - |
x * 56000, SDS-PAGE | Rattus norvegicus |
| 1.8.1.4 | 56000 | - |
x * 56000, SDS-PAGE | Azotobacter vinelandii |
| 1.8.1.4 | 56000 | - |
x * 56000, enzyme from liver enzyme | Rattus norvegicus |
| 1.8.1.4 | 58000 | - |
x * 58000, SDS-PAGE | Halobacterium salinarum |
| 1.8.1.4 | 58000 | - |
x * 58000, enzyme from heart, SDS-PAGE | Rattus norvegicus |
| 1.8.1.4 | 59000 | - |
x * 59000, SDS-PAGE | Pisum sativum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.4 | additional information | Saccharomyces pastorianus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? |  |
| 1.8.1.4 | additional information | Bacillus subtilis | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Escherichia coli | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Homo sapiens | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Rattus norvegicus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Sus scrofa | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Saccharomyces cerevisiae | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Bos taurus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Geobacillus stearothermophilus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Pisum sativum | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Pseudomonas aeruginosa | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Pseudomonas putida | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Halobacterium salinarum | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Ascaris suum | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| 1.8.1.4 | additional information | Azotobacter vinelandii | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.4 | Ascaris suum | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Azotobacter vinelandii | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Bacillus subtilis | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Bos taurus | - |
- |
- |
| 1.8.1.4 | Escherichia coli | - |
K-12 | - |
| 1.8.1.4 | Escherichia coli | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Geobacillus stearothermophilus | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Halobacterium salinarum | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Homo sapiens | - |
- |
- |
| 1.8.1.4 | Pisum sativum | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Pseudomonas aeruginosa | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Pseudomonas putida | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Rattus norvegicus | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Saccharomyces cerevisiae | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Saccharomyces pastorianus | - |
dihydrolipoamide dehydrogenase E3 | - |
| 1.8.1.4 | Sus scrofa | - |
dihydrolipoamide dehydrogenase E3 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.4 | brain | - |
Rattus norvegicus | - |
| 1.8.1.4 | brain | - |
Sus scrofa | - |
| 1.8.1.4 | heart | - |
Sus scrofa | - |
| 1.8.1.4 | heart | - |
Bos taurus | - |
| 1.8.1.4 | kidney | - |
Bos taurus | - |
| 1.8.1.4 | leaf | - |
Pisum sativum | - |
| 1.8.1.4 | liver | - |
Homo sapiens | - |
| 1.8.1.4 | liver | - |
Rattus norvegicus | - |
| 1.8.1.4 | muscle | - |
Ascaris suum | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Saccharomyces pastorianus | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Bacillus subtilis | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Escherichia coli | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Homo sapiens | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Rattus norvegicus | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Sus scrofa | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Saccharomyces cerevisiae | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Bos taurus | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Geobacillus stearothermophilus | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Pisum sativum | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Pseudomonas aeruginosa | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Pseudomonas putida | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Halobacterium salinarum | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Ascaris suum | lipoamide + NADH | - |
? | |
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Azotobacter vinelandii | lipoamide + NADH | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces pastorianus | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bacillus subtilis | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Escherichia coli | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Homo sapiens | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Rattus norvegicus | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Sus scrofa | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces cerevisiae | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bos taurus | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Geobacillus stearothermophilus | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pisum sativum | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas aeruginosa | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas putida | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Halobacterium salinarum | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Ascaris suum | ? | - |
? | |
| 1.8.1.4 | additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Azotobacter vinelandii | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.8.1.4 | ? | - |
Saccharomyces pastorianus |
| 1.8.1.4 | ? | - |
Homo sapiens |
| 1.8.1.4 | ? | x * 54000, SDS-PAGE | Geobacillus stearothermophilus |
| 1.8.1.4 | ? | x * 54000, SDS-PAGE | Ascaris suum |
| 1.8.1.4 | ? | x * 56000, SDS-PAGE | Rattus norvegicus |
| 1.8.1.4 | ? | x * 56000, SDS-PAGE | Azotobacter vinelandii |
| 1.8.1.4 | ? | x * 55000, SDS-PAGE | Bos taurus |
| 1.8.1.4 | ? | x * 58000, SDS-PAGE | Halobacterium salinarum |
| 1.8.1.4 | ? | x * 59000, SDS-PAGE | Pisum sativum |
| 1.8.1.4 | ? | x * 58000, enzyme from heart, SDS-PAGE | Rattus norvegicus |
| 1.8.1.4 | ? | x * 56000, enzyme from liver enzyme | Rattus norvegicus |
| 1.8.1.4 | ? | x * 49690, calculation from nucleotide sequence | Sus scrofa |
| 1.8.1.4 | ? | x * 51274, calculation from nucleotide sequence | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces pastorianus |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bacillus subtilis |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Escherichia coli |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Homo sapiens |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Rattus norvegicus |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Sus scrofa |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces cerevisiae |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bos taurus |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Geobacillus stearothermophilus |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pisum sativum |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas aeruginosa |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas putida |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Halobacterium salinarum |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Ascaris suum |
| 1.8.1.4 | dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Azotobacter vinelandii |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.4 | NAD+ | - |
Saccharomyces pastorianus | |
| 1.8.1.4 | NAD+ | - |
Bacillus subtilis | |
| 1.8.1.4 | NAD+ | - |
Escherichia coli | |
| 1.8.1.4 | NAD+ | - |
Homo sapiens | |
| 1.8.1.4 | NAD+ | - |
Rattus norvegicus | |
| 1.8.1.4 | NAD+ | - |
Sus scrofa | |
| 1.8.1.4 | NAD+ | - |
Saccharomyces cerevisiae | |
| 1.8.1.4 | NAD+ | - |
Bos taurus | |
| 1.8.1.4 | NAD+ | - |
Geobacillus stearothermophilus | |
| 1.8.1.4 | NAD+ | - |
Pisum sativum | |
| 1.8.1.4 | NAD+ | - |
Pseudomonas aeruginosa | |
| 1.8.1.4 | NAD+ | - |
Pseudomonas putida | |
| 1.8.1.4 | NAD+ | - |
Halobacterium salinarum | |
| 1.8.1.4 | NAD+ | - |
Ascaris suum | |
| 1.8.1.4 | NAD+ | - |
Azotobacter vinelandii | |
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