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Literature summary extracted from

  • Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
    Synthesis and function of 3-phosphorylated inositol lipids (2001), Annu. Rev. Biochem., 70, 535-602.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.153 additional information stimulation of almost every receptor that induces tyrosine kinase activity also leads to class IA phosphatidylinositol-4,5-bisphosphate 3-kinase activation Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.153 expression of P110delta in Sf9 insect cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.153
-
 Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.153 LY294002
-
 Homo sapiens
2.7.1.153 LY294002
-
 Mammalia
2.7.1.153 Wortmannin
-
 Homo sapiens
2.7.1.153 Wortmannin
-
 Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.153 cytosol
-
 Mammalia 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.153 additional information Homo sapiens
-
 ?
-
 ?
2.7.1.153 additional information Drosophila melanogaster enzyme can promote proliferation ?
-
 ?
2.7.1.153 additional information Mammalia enzyme can promote proliferation ?
-
 ?
2.7.1.153 additional information Drosophila melanogaster phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
2.7.1.153 additional information Mammalia phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
2.7.1.153 additional information Dictyostelium discoideum phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
2.7.1.153 additional information Caenorhabditis elegans phosphoinositide 3-kinase and DNA synthesis ?
-
 ?
2.7.1.153 additional information Drosophila melanogaster enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
2.7.1.153 additional information Mammalia enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
2.7.1.153 additional information Dictyostelium discoideum enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
2.7.1.153 additional information Caenorhabditis elegans enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear ?
-
 ?
2.7.1.153 additional information Drosophila melanogaster phosphoinositide 3-kinase and apoptosis ?
-
 ?
2.7.1.153 additional information Mammalia phosphoinositide 3-kinase and apoptosis ?
-
 ?
2.7.1.153 additional information Dictyostelium discoideum phosphoinositide 3-kinase and apoptosis ?
-
 ?
2.7.1.153 additional information Caenorhabditis elegans phosphoinositide 3-kinase and apoptosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Caenorhabditis elegans
-
-
-
2.7.1.137 Dictyostelium discoideum
-
-
-
2.7.1.137 Drosophila melanogaster
-
-
-
2.7.1.153 Caenorhabditis elegans
-
-
-
2.7.1.153 Dictyostelium discoideum
-
-
-
2.7.1.153 Drosophila melanogaster
-
-
-
2.7.1.153 Homo sapiens
-
-
-
2.7.1.153 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.153 leukocyte
-
 Mammalia
-
2.7.1.153 leukocyte
-
 Homo sapiens
-
2.7.1.153 MCF-7 cell
-
 Homo sapiens
-
2.7.1.153 MOLT-4 cell
-
 Homo sapiens
-
2.7.1.153 additional information all mammalian cell types investigated express at least one class IA isoform, class IB isoform is present only in mammals, where it shows a restricted tissue distribution, being abundant only in white blood cells Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Drosophila melanogaster ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Dictyostelium discoideum ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Caenorhabditis elegans ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Drosophila melanogaster ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Dictyostelium discoideum ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Caenorhabditis elegans ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol
-
 Drosophila melanogaster ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol
-
 Mammalia ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol
-
 Dictyostelium discoideum ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol
-
 Caenorhabditis elegans ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
-
 Drosophila melanogaster ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
-
 Mammalia ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
-
 Homo sapiens ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
-
 Dictyostelium discoideum ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
2.7.1.153 ATP + phosphatidylinositol 4-phosphate
-
 Caenorhabditis elegans ADP + phosphatidylinositol 4,5-diphosphate
-
 ?
2.7.1.153 additional information
-
 Homo sapiens ?
-
 ?
2.7.1.153 additional information enzyme can promote proliferation Drosophila melanogaster ?
-
 ?
2.7.1.153 additional information enzyme can promote proliferation Mammalia ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Drosophila melanogaster ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Mammalia ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Dictyostelium discoideum ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Caenorhabditis elegans ?
-
 ?
2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Drosophila melanogaster ?
-
 ?
2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Mammalia ?
-
 ?
2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Dictyostelium discoideum ?
-
 ?
2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Caenorhabditis elegans ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Drosophila melanogaster ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Mammalia ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Dictyostelium discoideum ?
-
 ?
2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Caenorhabditis elegans ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.153 More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Drosophila melanogaster
2.7.1.153 More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Mammalia
2.7.1.153 More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Dictyostelium discoideum
2.7.1.153 More class I phosphoinositide 3-kinases are heterodimers made up of an catalytic subunit, called p110, of about 110000 Da and an adaptor/regulatory subunit. Class I phosphoinositide 3-kinases are further subdivided into class Ia and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively Caenorhabditis elegans
2.7.1.153 More a single type of catalytic/adaptor heterodimer: AGE-1/AAP-1 Caenorhabditis elegans
2.7.1.153 More a single type of catalytic/adaptor heterodimer: Dp110/p60 Drosophila melanogaster
2.7.1.153 More three class IA p110 isoforms, p110alpha, beta and delta, which are encoded by three separate genes, at least seven adaptor proteins, which are generated by expression and alternative splicing of three different genes, namely p85alpha, p85beta and p55gamma. All these splice variants make functional complexes with p110 subunits Mammalia
2.7.1.153 More three catalytic subunits: PIK1, PIK2 or PIK3 Dictyostelium discoideum