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Literature summary extracted from

  • Hoek, J.B.; Rydström, J.
    Physiological roles of nicotinamide nucleotide transhydrogenase (1988), Biochem. J., 254, 1-10.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.1 NAD+ product inhibition of forward reaction i.e. reduction of NADP+ by NADH Mammalia
7.1.1.1 NADH product inhibition of reverse reaction i.e. reduction of NAD+ by NADPH Mammalia
7.1.1.1 NADP+ product inhibition of reverse reaction i.e. reduction of NAD+ by NADPH Mammalia
7.1.1.1 NADPH product inhibition of forward reaction i.e. reduction of NADP+ by NADH Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.1 mitochondrial membrane
-
 Mammalia 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.1 NADH + NADP+ Mammalia forward reaction NADPH + NAD+
-
 r
7.1.1.1 NADH + NADP+ Mammalia physiological role NADPH + NAD+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.1 Mammalia
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.1 NADH + NADP+ the reaction is coupled to a transmembrane proton translocation from cytosol to mitochondria Mammalia NAD+ + NADPH
-
 r
7.1.1.1 NADH + NADP+ forward reaction Mammalia NADPH + NAD+
-
 r
7.1.1.1 NADH + NADP+ physiological role Mammalia NADPH + NAD+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.1 NAD+
-
 Mammalia
7.1.1.1 NADH
-
 Mammalia
7.1.1.1 NADP+
-
 Mammalia
7.1.1.1 NADPH
-
 Mammalia