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Literature summary extracted from

  • Cook, R.J.; Misono, K.S.; Wagner, C.
    Identification of the covalently bound flavin of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria (1980), J. Biol. Chem., 259, 12475-12480.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.8.3 mitochondrion
-
 Rattus norvegicus 5739
-
1.5.8.4 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.8.3 sarcosine + acceptor + H2O Rattus norvegicus acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate glycine + formaldehyde + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor Rattus norvegicus reaction of the choline degradation pathway sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.8.3 Rattus norvegicus
-
-
-
1.5.8.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.8.3 liver
-
 Rattus norvegicus
-
1.5.8.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.8.3 sarcosine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus glycine + formaldehyde + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor reaction of the choline degradation pathway Rattus norvegicus sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.8.3 FAD covalent bound FAD linked via 8a-position of the isoalloxazin ring to the imidazole N(3) of a histidine residue, structural homology between the amino acid sequence of the flavin-peptides Rattus norvegicus
1.5.8.3 tetrahydrofolate
-
 Rattus norvegicus
1.5.8.4 FAD covalently bound Rattus norvegicus