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Literature summary extracted from

  • Kim, S.; Benoiton, L.; Woon Ki Paik
    Epsilon-alkyllysinase. Purification and properties of the enzyme (1964), J. Biol. Chem., 239, 3790-3796.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.3.4 phosphate stimulates enzyme in prepared mitochondrial fraction, but inhibits activity in crude homogenate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.4 ascorbic acid moderate inhibition Rattus norvegicus
1.5.3.4 Co2+ strong inhibitory effect Rattus norvegicus
1.5.3.4 FAD moderate inhibition Rattus norvegicus
1.5.3.4 FMN moderate inhibition Rattus norvegicus
1.5.3.4 KCN 1.3 mM, about 40% inhibition Rattus norvegicus
1.5.3.4 Mn2+ moderate inhibition Rattus norvegicus
1.5.3.4 additional information not inhibited by semicarbazide Rattus norvegicus
1.5.3.4 NADH moderate inhibition Rattus norvegicus
1.5.3.4 Ni2+ strong inhibitory effect Rattus norvegicus
1.5.3.4 phosphate inhibits activity in crude homogenate, but stimulates enzyme in prepared mitochondrial fraction Rattus norvegicus
1.5.3.4 Zn2+ strong inhibitory effect Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.4 0.87
-
N6,N6-dimethyl-L-lysine
-
Rattus norvegicus
1.5.3.4 1.63
-
N6-methyl-L-lysine
-
Rattus norvegicus
1.5.3.4 5.95
-
N6-ethyl-L-lysine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.3.4 mitochondrion 60% of the activity in rat kidney is present in the mitochondrial fraction Rattus norvegicus 5739
-
1.5.3.4 particle-bound
-
Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.4 Canis lupus familiaris
-
-
-
1.5.3.4 Cavia porcellus
-
-
-
1.5.3.4 Columba sp.
-
-
-
1.5.3.4 Felis catus
-
low activity
-
1.5.3.4 Gallus gallus
-
-
-
1.5.3.4 Mesocricetus auratus
-
-
-
1.5.3.4 Mus musculus
-
-
-
1.5.3.4 Oryctolagus cuniculus
-
-
-
1.5.3.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.3.4 2.78fold partial purification Rattus norvegicus
1.5.3.4 enzyme from kidney Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.3.4 kidney
-
Cavia porcellus
-
1.5.3.4 kidney
-
Mus musculus
-
1.5.3.4 kidney
-
Canis lupus familiaris
-
1.5.3.4 kidney highest activity Rattus norvegicus
-
1.5.3.4 kidney higher activity than in liver Gallus gallus
-
1.5.3.4 kidney higher activity than in liver Rattus norvegicus
-
1.5.3.4 kidney higher activity than in liver Oryctolagus cuniculus
-
1.5.3.4 kidney higher activity than in liver Mesocricetus auratus
-
1.5.3.4 kidney higher activity than in liver Felis catus
-
1.5.3.4 kidney higher activity than in liver Columba sp.
-
1.5.3.4 liver
-
Mus musculus
-
1.5.3.4 liver
-
Canis lupus familiaris
-
1.5.3.4 liver low activity Gallus gallus
-
1.5.3.4 liver low activity Cavia porcellus
-
1.5.3.4 liver low activity Columba sp.
-
1.5.3.4 liver lower activity than in kidney Gallus gallus
-
1.5.3.4 liver lower activity than in kidney Rattus norvegicus
-
1.5.3.4 liver lower activity than in kidney Oryctolagus cuniculus
-
1.5.3.4 liver lower activity than in kidney Mesocricetus auratus
-
1.5.3.4 liver lower activity than in kidney Felis catus
-
1.5.3.4 liver lower activity than in kidney Columba sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.3.4 0.0044
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.4 6-(methylamino)-2-oxohexanoic acid + H2O + O2 15% of the activity with N6-methyl-L-lysine Rattus norvegicus 6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
?
1.5.3.4 6-(methylamino)-2-oxohexanoic acid + H2O + O2 free alpha-amino group is not required for susceptibility Rattus norvegicus 6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
?
1.5.3.4 additional information not: delta-N-monomethyl-L-ornithine Rattus norvegicus ?
-
?
1.5.3.4 additional information not: several acyl derivatives, alpha-N-methyl-L-lysine Rattus norvegicus ?
-
?
1.5.3.4 additional information activity restricted to epsilon-N-alkyllysine derivatives Rattus norvegicus ?
-
?
1.5.3.4 N6,N6-dimethyl-L-lysine + O2 + H2O 46% of the activity with N6-methyl-L-lysine, it may be oxidized by a different enzyme Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6,N6-dimethyl-L-lysine + O2 + H2O enzyme consumes per molecule N6,N6-dimethyl-L-lysine one molecule of oxygen Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-ethyl-L-lysine + H2O + O2 about 50% of the activity with N6-methyl-L-lysine Rattus norvegicus L-lysine + acetaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-D-lysine + H2O + O2 11% of the activity with epsilon-N-methyl-L-lysine Rattus norvegicus D-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Gallus gallus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Cavia porcellus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Mus musculus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Oryctolagus cuniculus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Canis lupus familiaris L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Mesocricetus auratus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Felis catus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O
-
Columba sp. L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O highest enzyme activity Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?
1.5.3.4 N6-methyl-L-lysine + O2 + H2O enzyme consumes per mol N6-methyl-L-lysine half a mol of oxygen Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.3.4 38
-
assay at Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.5.3.4 additional information
-
enzyme is resistant to heat, far more stable in presence of substrates Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.3.4 7
-
partially purified enzyme Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.5.3.4 6 7.8 pH 6: about 10% of activity maximum, pH 7.8: about 15% of activity maximum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.3.4 FAD enzyme is most likely a flavoprotein Rattus norvegicus
1.5.3.4 additional information no cofactor requirement Rattus norvegicus