Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rood, J.I.; Laird, A.J.; Williams, J.W.
    Cloning of the Escherichia coli K-12 dihydrofolate reductase gene following mu-mediated transposition (1980), Gene, 8, 255-265.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.3 medicine enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.3 folA gene, into multicopy vector pBR322, gene enrichment by Mu-mediated transposition Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.3 additional information
-
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH
-
Escherichia coli 5,6,7,8-tetrahydrofolate + NADP+
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.3 37
-
assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADPH
-
Escherichia coli