EC Number | Application | Comment | Organism |
---|---|---|---|
1.5.1.3 | medicine | enzyme is a target of several anti-folate inhibitory drugs to combat bacteria, protozoa and cancer | Mycolicibacterium phlei |
EC Number | General Stability | Organism |
---|---|---|
1.5.1.3 | bovine serum albumin stabilizes purified enzyme | Mycolicibacterium phlei |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.3 | methotrexate | - |
Mycolicibacterium phlei | |
1.5.1.3 | trimethoprim | - |
Mycolicibacterium phlei |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.3 | 0.0086 | - |
7,8-dihydrofolate | - |
Mycolicibacterium phlei | |
1.5.1.3 | 0.035 | - |
NADPH | - |
Mycolicibacterium phlei |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 15000 | - |
SDS-PAGE | Mycolicibacterium phlei |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.3 | Mycolicibacterium phlei | - |
- |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | additional information | - |
- |
Mycolicibacterium phlei |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.3 | 7,8-dihydrofolate + NADPH | - |
Mycolicibacterium phlei | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 30 | - |
assay at | Mycolicibacterium phlei |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 45 | - |
3.5 h, no loss of activity in presence of bovine serum albumin | Mycolicibacterium phlei |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 7 | - |
- |
Mycolicibacterium phlei |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.3 | NADPH | - |
Mycolicibacterium phlei |