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Literature summary extracted from

  • Nagelschmidt, M.; Jaenicke, L.
    Dihydrofolate reductase from bakers yeast. Purification and properties (1972), Hoppe-Seyler's Z. Physiol. Chem., 353, 773-781.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 folate
-
Saccharomyces cerevisiae
1.5.1.3 iodoacetamide
-
Saccharomyces cerevisiae
1.5.1.3 methotrexate
-
Saccharomyces cerevisiae
1.5.1.3 N10-formylaminopterin
-
Saccharomyces cerevisiae
1.5.1.3 NADP+
-
Saccharomyces cerevisiae
1.5.1.3 p-chloromercuribenzoate
-
Saccharomyces cerevisiae
1.5.1.3 trimethoprim
-
Saccharomyces cerevisiae
1.5.1.3 Urea
-
Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.3 additional information
-
additional information
-
Saccharomyces cerevisiae
1.5.1.3 0.013
-
7,8-dihydrofolate
-
Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.3 39000
-
gel filtration Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.3
-
Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.3 1.75
-
purified enzyme Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH equilibrium constant: 320000000000 Saccharomyces cerevisiae 5,6,7,8-tetrahydrofolate + NADP+
-
r

Subunits

EC Number Subunits Comment Organism
1.5.1.3 monomer 1 * 39000, SDS-PAGE Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5.1.3 11.5
-
7,8-dihydrofolate
-
Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.3 6.8
-
-
Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADPH specific Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.3 0.0016
-
N10-formyldihydrofolate
-
Saccharomyces cerevisiae
1.5.1.3 0.0027
-
trimethoprim with N10-formyldihydrofolate Saccharomyces cerevisiae
1.5.1.3 0.025
-
folate with 7,8-dihydrofolate Saccharomyces cerevisiae
1.5.1.3 0.3
-
NADP+ with NADPH Saccharomyces cerevisiae