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Literature summary extracted from

  • Gutteridge, W.E.; McCormack, J.J.; Jaffee, J.J.
    Presence and properties of dihydrofolate reductases within the genus Crithidia (1969), Biochim. Biophys. Acta, 178, 453-458.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 folate at 0.1 mM Crithidia fasciculata
1.5.1.3 folate at 0.1 mM Strigomonas oncopelti
1.5.1.3 methotrexate
-
Crithidia fasciculata
1.5.1.3 methotrexate
-
Strigomonas oncopelti
1.5.1.3 additional information no effect of biopterin and dihydrobiopterin at 0.1 mM; overview Crithidia fasciculata
1.5.1.3 additional information no effect of biopterin and dihydrobiopterin at 0.1 mM; overview Strigomonas oncopelti
1.5.1.3 pyrimethamine
-
Crithidia fasciculata
1.5.1.3 pyrimethamine
-
Strigomonas oncopelti
1.5.1.3 trimethoprim
-
Crithidia fasciculata
1.5.1.3 trimethoprim
-
Strigomonas oncopelti

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.3 additional information
-
additional information
-
Crithidia fasciculata
1.5.1.3 additional information
-
additional information
-
Strigomonas oncopelti
1.5.1.3 0.003
-
7,8-dihydrofolate
-
Crithidia fasciculata
1.5.1.3 0.003
-
7,8-dihydrofolate
-
Strigomonas oncopelti
1.5.1.3 0.05
-
NADPH
-
Crithidia fasciculata
1.5.1.3 0.05
-
NADPH
-
Strigomonas oncopelti

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Crithidia fasciculata
-
-
-
1.5.1.3 Strigomonas oncopelti
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH
-
Crithidia fasciculata 5,6,7,8-tetrahydrofolate + NADP+
-
?
1.5.1.3 7,8-dihydrofolate + NADPH + H+
-
Strigomonas oncopelti 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 folate + NADPH no activity Crithidia fasciculata 5,6,7,8-tetrahydrofolate + NADP+
-
?
1.5.1.3 folate + NADPH no activity Strigomonas oncopelti 5,6,7,8-tetrahydrofolate + NADP+
-
?
1.5.1.3 additional information no activity with 7,8-dihydrobiopterin and biopterin Crithidia fasciculata ?
-
?
1.5.1.3 additional information no activity with 7,8-dihydrobiopterin and biopterin Strigomonas oncopelti ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.3 6 7
-
Crithidia fasciculata
1.5.1.3 6 7
-
Strigomonas oncopelti

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.5.1.3 5.5 8.8 half-maximal activities at pH 5.5 and pH 8.8 Crithidia fasciculata
1.5.1.3 5.5 7.8 half-maximal activities at pH 5.5 and pH 7.8 Strigomonas oncopelti

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADH not Crithidia fasciculata
1.5.1.3 NADH not Strigomonas oncopelti