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Literature summary extracted from

  • Adams, E.; Goldstone, A.
    Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta 1-pyrroline-3-hydroxy-5-carboxylate (1960), J. Biol. Chem., 235, 3499-3503.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.2 D-allohydroxyproline competitive inhibition Bos taurus
1.5.1.2 imidazole
-
 Bos taurus
1.5.1.2 L-hydroxyproline competitive inhibition Bos taurus
1.5.1.2 proline competitive inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.2 4.4
-
 DELTA1-pyrroline-3-hydroxy-5-carboxylate
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.2
-
 Bos taurus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.2 additional information
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.5.1.2 -15°C, glutathione, EDTA Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.2 1-pyrroline-3-hydroxy-5-carboxylate + NAD(P)H
-
 Bos taurus L-hydroxyproline + NAD(P)+
-
 ir
1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
 Bos taurus L-proline + NAD(P)+
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.2 7 8
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.2 NADH
-
 Bos taurus
1.5.1.2 NADPH
-
 Bos taurus