Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Adams, E.; Goldstone, A.
    Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from DELTA1-pyrroline-3-hydroxy-5-carboxylate (1960), J. Biol. Chem., 235, 3504-3512.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.2.1.88 glutathione stabilizes Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.88 arsenate
-
 Bos taurus
1.2.1.88 arsenite
-
 Bos taurus
1.2.1.88 Borate
-
 Bos taurus
1.2.1.88 DELTA1-pyrroline-2-carboxylate
-
 Bos taurus
1.2.1.88 EDTA
-
 Bos taurus
1.2.1.88 fluoride
-
 Bos taurus
1.2.1.88 imidazole
-
 Bos taurus
1.2.1.88 L-hydroxyproline
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.88 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.88 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.88 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Bos taurus L-glutamate + NADH
-
 ?
1.2.1.88 DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O
-
 Bos taurus 4-hydroxyglutamate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.88 7.4
-
 1-pyrroline-3-hydroxy-5-carboxylate Bos taurus