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Literature summary extracted from

  • Sebela, M.; Luhova, L.; Frebort, I.; Faulhammer, H.G.; Hirota, S.; Zajoncova, L.; Stuzka, V.; Pec, P.
    Analysis of the active sites of copper/topa quinone-containing amine oxidases from Lathyrus odoratus and L. sativus seedlings (1998), Phytochem. Anal., 9, 211-222.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 1,4-Diamino-2-butanone
-
 Lathyrus odoratus
1.4.3.22 1,4-Diamino-2-butanone
-
 Lathyrus sativus
1.4.3.22 1,5-Diamino-3-pentanone
-
 Lathyrus odoratus
1.4.3.22 1,5-Diamino-3-pentanone
-
 Lathyrus sativus
1.4.3.22 2,2'-dipyridiyl
-
 Lathyrus odoratus
1.4.3.22 2,2'-dipyridyl
-
 Lathyrus odoratus
1.4.3.22 aminoacetonitrile
-
 Lathyrus odoratus
1.4.3.22 aminoacetonitrile
-
 Lathyrus sativus
1.4.3.22 aminoguanidine
-
 Lathyrus odoratus
1.4.3.22 aminoguanidine
-
 Lathyrus sativus
1.4.3.22 beta-aminopropionitrile
-
 Lathyrus odoratus
1.4.3.22 beta-aminopropionitrile
-
 Lathyrus sativus
1.4.3.22 hydroxylamine
-
 Lathyrus odoratus
1.4.3.22 hydroxylamine
-
 Lathyrus sativus
1.4.3.22 Hydroxyquinoline
-
 Lathyrus odoratus
1.4.3.22 Hydroxyquinoline
-
 Lathyrus sativus
1.4.3.22 o-phenanthroline
-
 Lathyrus odoratus
1.4.3.22 o-phenanthroline
-
 Lathyrus sativus
1.4.3.22 triethyltetramine
-
 Lathyrus odoratus
1.4.3.22 triethyltetramine
-
 Lathyrus sativus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.09
-
 3-hydroxycadaverine
-
 Lathyrus sativus
1.4.3.22 0.09
-
 3-hydroxycadaverine
-
 Lathyrus odoratus
1.4.3.22 0.1
-
 cystamine
-
 Lathyrus sativus
1.4.3.22 0.1
-
 cystamine
-
 Lathyrus odoratus
1.4.3.22 0.1
-
 (E)-1,4-diamino-2-butene
-
 Lathyrus sativus
1.4.3.22 0.1
-
 (E)-1,4-diamino-2-butene
-
 Lathyrus odoratus
1.4.3.22 0.11
-
 1,6-diaminohexane
-
 Lathyrus sativus
1.4.3.22 0.11
-
 1,6-diaminohexane
-
 Lathyrus odoratus
1.4.3.22 0.13
-
 cadaverine
-
 Lathyrus sativus
1.4.3.22 0.13
-
 cadaverine
-
 Lathyrus odoratus
1.4.3.22 0.3
-
 putrescine
-
 Lathyrus sativus
1.4.3.22 0.3
-
 putrescine
-
 Lathyrus odoratus
1.4.3.22 0.5
-
 agmatine
-
 Lathyrus sativus
1.4.3.22 0.5
-
 agmatine
-
 Lathyrus odoratus
1.4.3.22 0.67
-
 2-hydroxyputrescine
-
 Lathyrus sativus
1.4.3.22 0.67
-
 2-hydroxyputrescine
-
 Lathyrus odoratus
1.4.3.22 1.45
-
 spermidine
-
 Lathyrus sativus
1.4.3.22 1.67
-
 spermidine
-
 Lathyrus odoratus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.22 72000
-
 2 * 72000, SDS-PAGE Lathyrus sativus
1.4.3.22 72000
-
 2 * 72000, SDS-PAGE Lathyrus odoratus
1.4.3.22 140000
-
 gel filtration Lathyrus odoratus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Lathyrus odoratus
-
 sweet pea
-
1.4.3.22 Lathyrus sativus
-
 grass pea
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.22 glycoprotein 13% neutral sugars Lathyrus sativus
1.4.3.22 glycoprotein 10.6% neutral sugars Lathyrus odoratus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.22 ammonium sulfate, heat denaturation, DEAE-cellulose, hydroxyapatite, Sephacryl S-300 HR Lathyrus sativus
1.4.3.22 ammonium sulfate, heat denaturation, DEAE-cellulose, hydroxyapatite, Sephacryl S-300 HR Lathyrus odoratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 seedling
-
 Lathyrus sativus
-
1.4.3.22 seedling
-
 Lathyrus odoratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.22 48.61
-
-
 Lathyrus odoratus
1.4.3.22 64.25
-
-
 Lathyrus sativus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 (E)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus sativus 4-aminobut-2-enal + NH3 + H2O2
-
 r
1.4.3.22 (E)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus odoratus 4-aminobut-2-enal + NH3 + H2O2
-
 r
1.4.3.22 (E,Z)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus sativus 4-aminobut-2-enal + NH3 + H2O2
-
 ?
1.4.3.22 (E,Z)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus odoratus 4-aminobut-2-enal + NH3 + H2O2
-
 ?
1.4.3.22 1,4-diaminobutane + H2O + O2
-
 Lathyrus sativus 4-aminobutanal + NH3 + H2O2
-
 ?
1.4.3.22 1,4-diaminobutane + H2O + O2
-
 Lathyrus odoratus 4-aminobutanal + NH3 + H2O2
-
 ?
1.4.3.22 1,5-diaminopentane + H2O + O2
-
 Lathyrus sativus 5-aminopentanal + NH3 + H2O2
-
 ?
1.4.3.22 1,5-diaminopentane + H2O + O2
-
 Lathyrus odoratus 5-aminopentanal + NH3 + H2O2
-
 ?
1.4.3.22 1,6-diaminohexane + H2O + O2
-
 Lathyrus sativus 6-aminohexanal + NH3 + H2O2
-
 ?
1.4.3.22 1,6-diaminohexane + H2O + O2
-
 Lathyrus odoratus 6-aminohexanal + NH3 + H2O2
-
 ?
1.4.3.22 2-hydroxyputrescine + H2O + O2
-
 Lathyrus sativus 2-hydroxy-4-aminobutanal + H2O2 + NH3
-
 ?
1.4.3.22 2-hydroxyputrescine + H2O + O2
-
 Lathyrus odoratus 2-hydroxy-4-aminobutanal + H2O2 + NH3
-
 ?
1.4.3.22 3-hydroxycadaverine + H2O + O2
-
 Lathyrus sativus 3-hydroxy-4-aminopentanal + H2O2 + NH3
-
 ?
1.4.3.22 3-hydroxycadaverine + H2O + O2
-
 Lathyrus odoratus 3-hydroxy-4-aminopentanal + H2O2 + NH3
-
 ?
1.4.3.22 agmatine
-
 Lathyrus sativus ?
-
 ?
1.4.3.22 agmatine
-
 Lathyrus odoratus ?
-
 ?
1.4.3.22 cystamine + H2O + O2
-
 Lathyrus sativus 2-mercaptoethanal + H2O2 + NH3
-
 ?
1.4.3.22 cystamine + H2O + O2
-
 Lathyrus odoratus 2-mercaptoethanal + H2O2 + NH3
-
 ?
1.4.3.22 p-dimethylaminomethylbenzylamine + H2O + O2
-
 Lathyrus sativus p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 p-dimethylaminomethylbenzylamine + H2O + O2
-
 Lathyrus odoratus p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 RCH2NH2 + H2O + O2 very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine Lathyrus sativus RCHO + NH3 + H2O2
-
 ?
1.4.3.22 RCH2NH2 + H2O + O2 very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine Lathyrus odoratus RCHO + NH3 + H2O2
-
 ?
1.4.3.22 spermidine + H2O + O2
-
 Lathyrus sativus ?
-
 ?
1.4.3.22 spermidine + H2O + O2
-
 Lathyrus odoratus ?
-
 ?
1.4.3.22 tyramine + H2O + O2
-
 Lathyrus sativus 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 tyramine + H2O + O2
-
 Lathyrus odoratus 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.22 dimer 2 * 72000, SDS-PAGE Lathyrus sativus
1.4.3.22 dimer 2 * 72000, SDS-PAGE Lathyrus odoratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.22 6.8 7.8 depending on substrate Lathyrus sativus
1.4.3.22 6.8 7.8 depending on substrate Lathyrus odoratus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.22 0.02
-
 1,4-Diamino-2-butanone
-
 Lathyrus sativus
1.4.3.22 0.02
-
 1,4-Diamino-2-butanone
-
 Lathyrus odoratus
1.4.3.22 0.026
-
 1,5-Diamino-3-pentanone
-
 Lathyrus sativus
1.4.3.22 0.026
-
 1,5-Diamino-3-pentanone
-
 Lathyrus odoratus
1.4.3.22 0.5
-
 aminoguanidine apparent value Lathyrus sativus
1.4.3.22 0.5
-
 aminoguanidine apparent value Lathyrus odoratus
1.4.3.22 0.5
-
 aminoacetonitrile apparent value Lathyrus sativus
1.4.3.22 0.5
-
 aminoacetonitrile apparent value Lathyrus odoratus
1.4.3.22 2
-
 triethylentetramine
-
 Lathyrus sativus
1.4.3.22 2
-
 triethylentetramine
-
 Lathyrus odoratus
1.4.3.22 6.5
-
 beta-aminopropionitrile
-
 Lathyrus sativus
1.4.3.22 9
-
 beta-aminopropionitrile
-
 Lathyrus odoratus
1.4.3.22 14
-
 diethylentriamine
-
 Lathyrus odoratus
1.4.3.22 16
-
 o-phenanthroline
-
 Lathyrus sativus
1.4.3.22 16
-
 diethylentriamine
-
 Lathyrus odoratus
1.4.3.22 18
-
 o-phenanthroline
-
 Lathyrus odoratus
1.4.3.22 20
-
 Hydroxyquinoline
-
 Lathyrus sativus
1.4.3.22 35
-
 Hydroxyquinoline
-
 Lathyrus odoratus
1.4.3.22 50
-
 2,2'-dipyridiyl
-
 Lathyrus odoratus
1.4.3.22 75
-
 2,2'-dipyridyl
-
 Lathyrus odoratus