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Literature summary extracted from

  • Meister, A.; Wellner, D.
    Flavoprotein amino acid oxidases (1963), The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 7, 609-648.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.2
-
 Rattus norvegicus
1.4.3.2
-
 Crotalus adamanteus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.2 benzoic acid
-
 Agkistrodon piscivorus piscivorus
1.4.3.2 benzoic acid
-
 Crotalus adamanteus
1.4.3.2 benzoic acid
-
 Rattus norvegicus
1.4.3.2 CuSO4
-
 Rattus norvegicus
1.4.3.2 iodoacetic acid
-
 Agkistrodon piscivorus piscivorus
1.4.3.2 iodoacetic acid
-
 Crotalus adamanteus
1.4.3.2 iodoacetic acid
-
 Rattus norvegicus
1.4.3.2 NH4+ inhibition of amino acid oxidase activity, no inhibition of L-hydroxy acid oxidase activity Agkistrodon piscivorus piscivorus
1.4.3.2 NH4+ inhibition of amino acid oxidase activity, no inhibition of L-hydroxy acid oxidase activity Crotalus adamanteus
1.4.3.2 NH4+ inhibition of amino acid oxidase activity, no inhibition of L-hydroxy acid oxidase activity Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.2 138000
-
 calculation from diffusion constant, sedimentation coefficient and FAD content Rattus norvegicus
1.4.3.2 150000
-
 approach to equilibrium method Agkistrodon piscivorus piscivorus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.2 Agkistrodon piscivorus piscivorus
-
 cottonmouth moccasin
-
1.4.3.2 Crotalus adamanteus
-
-
-
1.4.3.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.2
-
 Rattus norvegicus
1.4.3.2
-
 Crotalus adamanteus
1.4.3.2
-
 Agkistrodon piscivorus piscivorus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.4.3.2 an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 mechanism Rattus norvegicus
a
1.4.3.2 an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 mechanism Crotalus adamanteus
a
1.4.3.2 an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 mechanism Agkistrodon piscivorus piscivorus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.2 kidney
-
 Rattus norvegicus
-
1.4.3.2 liver
-
 Rattus norvegicus
-
1.4.3.2 venom
-
 Crotalus adamanteus
-
1.4.3.2 venom
-
 Agkistrodon piscivorus piscivorus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.2 L-amino acid + H2O + O2
-
 Crotalus adamanteus 2-oxo acid + NH3 + H2O2
-
 ?
1.4.3.2 L-amino acid + H2O + O2
-
 Agkistrodon piscivorus piscivorus 2-oxo acid + NH3 + H2O2
-
 ?
1.4.3.2 L-amino acid + H2O + O2 other electron acceptors: methylene blue Rattus norvegicus 2-oxo acid + NH3 + H2O2
-
 ?
1.4.3.2 L-lactic acid + H2O + O2
-
 Rattus norvegicus pyruvate + NH3 + H2O2
-
 ?
1.4.3.2 additional information not: alpha-hydroxyisobutyrate Rattus norvegicus ?
-
 ?
1.4.3.2 additional information proline and N-methyl derivatives of leucine, methionine, homocysteine and S-benzylhomocysteine also oxidized Rattus norvegicus ?
-
 ?
1.4.3.2 additional information proline and N-methyl derivatives of leucine, methionine, homocysteine and S-benzylhomocysteine also oxidized Crotalus adamanteus ?
-
 ?
1.4.3.2 additional information proline and N-methyl derivatives of leucine, methionine, homocysteine and S-benzylhomocysteine also oxidized Agkistrodon piscivorus piscivorus ?
-
 ?
1.4.3.2 additional information not: D-amino acids, N,N-dimethylleucine, alpha-aminoisobutyric acid Rattus norvegicus ?
-
 ?
1.4.3.2 additional information not: D-amino acids, N,N-dimethylleucine, alpha-aminoisobutyric acid Crotalus adamanteus ?
-
 ?
1.4.3.2 additional information not: D-amino acids, N,N-dimethylleucine, alpha-aminoisobutyric acid Agkistrodon piscivorus piscivorus ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.4.3.2 70
-
 rapid loss of activity Agkistrodon piscivorus piscivorus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.2 7.2 7.5
-
 Rattus norvegicus
1.4.3.2 7.2 7.5
-
 Crotalus adamanteus
1.4.3.2 7.2 7.5
-
 Agkistrodon piscivorus piscivorus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.2 FAD
-
 Rattus norvegicus
1.4.3.2 FAD 2 mol of FAD per mol of enzyme Crotalus adamanteus
1.4.3.2 FAD 2 mol of FAD per mol of enzyme Agkistrodon piscivorus piscivorus