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Literature summary extracted from

  • Smith-Mungo, L.I.; Kagan, H.M.
    Lysyl oxidase: properties, regulation and multiple functions in biology (1998), Matrix Biol., 16, 387-398.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.13 transforming growth factor-beta1 fibrogenic cytokine, strongly promotes enzyme expression in fibroblasts of neonatal rat lung, human embryos and rat vascular smooth muscle cells Homo sapiens
1.4.3.13 transforming growth factor-beta1 fibrogenic cytokine, strongly promotes enzyme expression in fibroblasts of neonatal rat lung, human embryos and rat vascular smooth muscle cells Rattus norvegicus

Application

EC Number Application Comment Organism
1.4.3.13 medicine cutis laxa, indicated by hyperextensible skin with marked deficiency of skin elastic fibers, is caused by deficiency of lysyl oxidase expression. Fibrosis is a symptom of scleroderma, where lysyl oxidase is markedly elevated in affected tissues. Menkes syndrome may involve abnormalities in the expression of several genes coding for connective tissue proteins Mammalia
1.4.3.13 medicine increase in the expression of lysyl oxidase during wound healing in skin and in aorta, lung and skin of developing and aging rats. Implication of lysyl oxidase as a target gene for IRF-1 in tumor suppression. Lysly oxidase has unusual and important roles in cellular homeostasis Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.13
-
 Gallus gallus
1.4.3.13
-
 Homo sapiens
1.4.3.13
-
 Mus musculus
1.4.3.13 expressed in Escherichia coli Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 basic fibroblast growth factor reduces enzyme expression in osteogenic cells Mammalia
1.4.3.13 beta-aminopropionitrile
-
 Gallus gallus
1.4.3.13 beta-aminopropionitrile irreversible inhibitor Rattus norvegicus
1.4.3.13 cycloheximide
-
 Gallus gallus
1.4.3.13 cycloheximide prevents stimulation by transforming growth factor-beta1 Mammalia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.13 Cu2+
-
 Gallus gallus
1.4.3.13 Cu2+ copper-binding and -dependent Homo sapiens
1.4.3.13 Cu2+ tightly bound in a tetragonally distorted, octahedrally coordinated ligand field, one per mol Mammalia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.13 32000
-
 x * 46000, predicted, x * 32000, SDS-PAGE Bos taurus
1.4.3.13 32000
-
 x * 32000, catalytically active enzyme after proteolytic cleavage Mammalia
1.4.3.13 32000
-
 x * 32000, catalytically active enzyme after proteolytic cleavage Rattus norvegicus
1.4.3.13 46000
-
 x * 46000, predicted, x * 32000, SDS-PAGE Bos taurus
1.4.3.13 50000
-
 x * 50000, preproprotein Mammalia

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Bos taurus
-
-
-
1.4.3.13 Gallus gallus
-
-
-
1.4.3.13 Homo sapiens
-
-
-
1.4.3.13 Mammalia
-
 expression is sensitively modulated by specific cytokines, growth factors and related intercellular molecular messengers
-
1.4.3.13 Mus musculus
-
-
-
1.4.3.13 Ovis aries
-
-
-
1.4.3.13 Rattus norvegicus
-
-
-
1.4.3.13 Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.13 glycoprotein
-
 Homo sapiens
1.4.3.13 glycoprotein N-glycosylated as 50 kDa preproprotein Mammalia
1.4.3.13 proteolytic modification proteolytically cleaved to the 32 kDa catalytically active enzyme Mammalia

Reaction

EC Number Reaction Comment Organism Reaction ID
1.4.3.13 [protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 preprotein, lysyl oxidase gene family, amine oxidation through ping pong bi ter kinetic mechanism Mammalia
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 aorta
-
 Gallus gallus
-
1.4.3.13 aorta
-
 Rattus norvegicus
-
1.4.3.13 aorta
-
 Bos taurus
-
1.4.3.13 basal cell
-
 Mammalia
-
1.4.3.13 biliary epithelium
-
 Mammalia
-
1.4.3.13 chondrocyte
-
 Mammalia
-
1.4.3.13 endothelium
-
 Mammalia
-
1.4.3.13 fibroblast
-
 Homo sapiens
-
1.4.3.13 fibroblast
-
 Mammalia
-
1.4.3.13 glomerular epithelium
-
 Mammalia
-
1.4.3.13 lung
-
 Rattus norvegicus
-
1.4.3.13 skin
-
 Homo sapiens
-
1.4.3.13 skin
-
 Rattus norvegicus
-
1.4.3.13 smooth muscle
-
 Mammalia
-
1.4.3.13 smooth muscle nucleus Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Gallus gallus peptidyl-L-allysyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O crosslinkage in fibrillar collagen and elastin Mammalia peptidyl-L-allysyl-peptide + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.13 ?
-
 Gallus gallus
1.4.3.13 ?
-
 Homo sapiens
1.4.3.13 ? x * 46000, predicted, x * 32000, SDS-PAGE Bos taurus
1.4.3.13 ? x * 32000, catalytically active enzyme after proteolytic cleavage Mammalia
1.4.3.13 ? x * 32000, catalytically active enzyme after proteolytic cleavage Rattus norvegicus
1.4.3.13 ? x * 50000, preproprotein Mammalia

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 lysyl oxidase
-
 Mammalia
1.4.3.13 lysyl oxidase amine oxidase, oxidative deamination Gallus gallus
1.4.3.13 lysyl oxidase amine oxidase, oxidative deamination Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.13 lysyltyrosyl quinone
-
 Homo sapiens
1.4.3.13 lysyltyrosyl quinone prosthetic group Mammalia
1.4.3.13 trihydroxyphenylalanine quinone
-
 Saccharomyces cerevisiae