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Literature summary extracted from

  • Dixon, M.; Kenworthy, P.
    D-aspartate oxidase of kidney (1967), Biochim. Biophys. Acta, 146, 54-76.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.1 2-oxoglutaric acid at 6.67 mM 64% inhibition Oryctolagus cuniculus
1.4.3.1 adipic acid at 6.67 mM 15% inhibition Oryctolagus cuniculus
1.4.3.1 Citric acid at 6.67 mM 29% inhibition Oryctolagus cuniculus
1.4.3.1 D-malate 90% inhibition at 0.33 mM Oryctolagus cuniculus
1.4.3.1 D-Tartaric acid at 6.67 mM 77% inhibition Oryctolagus cuniculus
1.4.3.1 Fumaric acid at 6.67 mM 78% inhibition Oryctolagus cuniculus
1.4.3.1 Glutaric acid at 6.67 mM 62% inhibition Oryctolagus cuniculus
1.4.3.1 L-leucine 6% inhibition at 6.67 mM Oryctolagus cuniculus
1.4.3.1 L-Malic acid at 6.67 mM 79% inhibition Oryctolagus cuniculus
1.4.3.1 L-Tartaric acid at 6.67 mM 24% inhibition Oryctolagus cuniculus
1.4.3.1 L-valine 6% inhibition at 6.67 mM Oryctolagus cuniculus
1.4.3.1 malonate at 0.66 mM 78% inhibition Oryctolagus cuniculus
1.4.3.1 oxalic acid at 6.67 mM 40% inhibition Oryctolagus cuniculus
1.4.3.1 oxaloacetic acid at 6.67 mM 90% inhibition Oryctolagus cuniculus
1.4.3.1 succinic acid at 6.67 mM 66% inhibition Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.1 0.86
-
 D-Aspartate O2 as acceptor Oryctolagus cuniculus
1.4.3.1 5.2
-
 D-Aspartate ferricyanide as acceptor Oryctolagus cuniculus
1.4.3.1 5.7
-
 D-glutamate ferricyanide as acceptor Oryctolagus cuniculus
1.4.3.1 166
-
 D-glutamate O2 as acceptor Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2 Oryctolagus cuniculus
-
 oxaloacetate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.1 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.1
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.1 kidney
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.1 2.4
-
 ferricyanide as electron acceptor Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2
-
 Oryctolagus cuniculus oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.1 D-aspartate + H2O + O2 ferricyanide and 2,6-dichlorophenolindophenol can also act as electron acceptors instead of O2 Oryctolagus cuniculus oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.1 D-glutamate + H2O + O2 ferricyanide and 2,6-dichlorophenolindophenol can also act as electron acceptors instead of O2 Oryctolagus cuniculus 2-oxoglutarate + NH3 + H2O2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.1 additional information
-
 optimum depends on the order of addition of the reactands Oryctolagus cuniculus
1.4.3.1 9.5
-
-
 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.1 4.5 11 largely destroyed below or over this range Oryctolagus cuniculus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.4.3.1 6 8.5 fairly stable Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.1 0.011
-
 D-malate
-
 Oryctolagus cuniculus
1.4.3.1 0.06
-
 malonate
-
 Oryctolagus cuniculus