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Literature summary extracted from

  • Nguyen, K.T.; Nguyen, L.T.; Behal, V.
    The introduction of valine dehydrogenase activity from Streptomyces by L-valine is not repressed by ammonium (1995), Biotechnol. Lett., 17, 31-34.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.1.8 L-valine L-valine in growth medium induces VDH activity, not interfered by ammonia Streptomyces fradiae
1.4.1.8 L-valine L-valine in growth medium induces VDH activity, not interfered by ammonia Kitasatospora aureofaciens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.8 L-valine + NAD(P)+ + H2O Streptomyces fradiae metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Streptomyces fradiae first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens BS-5 metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens BS-5 first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Streptomyces fradiae 30/3 metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O Streptomyces fradiae 30/3 first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.8 Kitasatospora aureofaciens
-
-
-
1.4.1.8 Kitasatospora aureofaciens
-
 crude extract
-
1.4.1.8 Kitasatospora aureofaciens BS-5
-
-
-
1.4.1.8 Streptomyces fradiae
-
-
-
1.4.1.8 Streptomyces fradiae
-
 crude extract
-
1.4.1.8 Streptomyces fradiae 30/3
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.1.8 additional information
-
 effect of L-valine and ammonium in different growth media on the VDH specific activity in crude extract Streptomyces fradiae
1.4.1.8 additional information
-
 effect of L-valine and ammonium in different growth media on the VDH specific activity in crude extract Kitasatospora aureofaciens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.8 L-valine + NAD(P)+ + H2O
-
 Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O
-
 Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O
-
 Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O
-
 Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
1.4.1.8 L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?