EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.4.1.14 | 2-hydroxyglutarate | D- and L-isomer, most potent competitive inhibitor | Lupinus angustifolius | |
1.4.1.14 | 2-oxoglutarate | - |
Lupinus angustifolius | |
1.4.1.14 | aspartate | weak inhibition, competitive with 2-oxoglutarate | Lupinus angustifolius | |
1.4.1.14 | D-2-hydroxyglutarate | - |
Lupinus angustifolius | |
1.4.1.14 | D-glutamate | competitive inhibitor | Lupinus angustifolius | |
1.4.1.14 | Glutarate | most potent competitive inhibitor | Lupinus angustifolius | |
1.4.1.14 | L-2-hydroxyglutarate | - |
Lupinus angustifolius | |
1.4.1.14 | L-glutamate | competitive with 2-oxoglutarate | Lupinus angustifolius | |
1.4.1.14 | oxaloacetate | weak inhibition, competitive with 2-oxoglutarate | Lupinus angustifolius |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.1.14 | 0.024 | - |
2-oxoglutarate | - |
Lupinus angustifolius |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.1.14 | L-glutamine + 2-oxoglutarate + NADH | Lupinus angustifolius | ammonia assimilation from fixed nitrogen, de novo synthesis of glutamate | glutamate + NAD+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.4.1.14 | Lupinus angustifolius | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.4.1.14 | root nodule | - |
Lupinus angustifolius | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.1.14 | L-glutamine + 2-oxoglutarate + NADH | absolute specificity for 2-oxoglutarate | Lupinus angustifolius | L-glutamate + NAD+ | - |
? | |
1.4.1.14 | L-glutamine + 2-oxoglutarate + NADH | ammonia assimilation from fixed nitrogen, de novo synthesis of glutamate | Lupinus angustifolius | glutamate + NAD+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.4.1.14 | NADH | - |
Lupinus angustifolius |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.1.14 | 0.25 | - |
L-2-hydroxyglutarate | - |
Lupinus angustifolius | |
1.4.1.14 | 0.28 | - |
D-2-hydroxyglutarate | - |
Lupinus angustifolius | |
1.4.1.14 | 0.35 | - |
Glutarate | - |
Lupinus angustifolius | |
1.4.1.14 | 0.6 | - |
L-glutamate | - |
Lupinus angustifolius | |
1.4.1.14 | 0.6 | - |
D-glutamate | - |
Lupinus angustifolius | |
1.4.1.14 | 2.7 | - |
L-aspartate | - |
Lupinus angustifolius | |
1.4.1.14 | 5 | - |
oxaloacetate | - |
Lupinus angustifolius |