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Literature summary extracted from

  • Ikeda, Y.; Hine, D.G.; Okamura-Ikeda, K.; Tanaka, K.
    Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange (1985), J. Biol. Chem., 260, 1326-1337.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.7 HgCl2
-
Rattus norvegicus
1.3.8.7 Methylmercury iodide
-
Rattus norvegicus
1.3.8.7 p-chloromercuribenzoate
-
Rattus norvegicus
1.3.8.8 HgCl2 inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions Rattus norvegicus
1.3.8.8 Methylmercury iodide inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions Rattus norvegicus
1.3.8.8 p-chloromercuribenzoate inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.8.8 mitochondrion
-
Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.1 Rattus norvegicus
-
-
-
1.3.8.7 Rattus norvegicus
-
-
-
1.3.8.8 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.7
-
Rattus norvegicus
1.3.8.8
-
Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.8.1 a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein mechanism Rattus norvegicus
1.3.8.7 a medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein mechanism, proton abstraction from C-2 of the substrate and hydride transfer from C-3 to the N-5 position of the flavin Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.8.1 liver
-
Rattus norvegicus
-
1.3.8.7 liver
-
Rattus norvegicus
-
1.3.8.8 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.1 pentanoyl-CoA + phenazine methosulfate
-
Rattus norvegicus 2-pentenoyl-CoA + reduced acceptor
-
?
1.3.8.8 additional information enzyme-catalyzed proton-deuteron exchange experiments in absence of an electron acceptor, deuterium atom replaces hydrogen from C-2 giving experimental evidence for the initial C-2 proton abstraction Rattus norvegicus ?
-
?
1.3.8.8 palmitoyl-CoA + electron-transfer flavoprotein
-
Rattus norvegicus 2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.8.1 3
-
pentanoyl-CoA C-2 proton/deuteron exchange Rattus norvegicus
1.3.8.1 24.5
-
pentanoyl-CoA
-
Rattus norvegicus
1.3.8.7 3.3
-
octanoyl-CoA C-2 proton/deuteron exchange Rattus norvegicus
1.3.8.7 27.2
-
octanoyl-CoA
-
Rattus norvegicus
1.3.8.8 0.5
-
palmitoyl-CoA enzyme-catalyzed C-2 proton-deuteron exchange reaction Rattus norvegicus
1.3.8.8 5.4
-
palmitoyl-CoA
-
Rattus norvegicus