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Literature summary extracted from

  • Ikeda, Y.; Tanaka, K.
    Selective inactivation of various acyl-CoA dehydrogenases by (methylenecyclopropyl)acetyl-CoA (1990), Biochim. Biophys. Acta, 1038, 216-221.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.1 (methylenecyclopropyl)acetyl-CoA 0.0025 mM, 50% inhibition after 2.2 min, preincubation with 1 molar substrate/enzyme equivalent of butyryl-CoA increases half-life to 38 min Rattus norvegicus
1.3.8.5 (methylenecyclopropyl)acetyl-CoA 0.0025 mM, slow inhibition, half-time approx. 30 min Rattus norvegicus
1.3.8.7 (methylenecyclopropyl)acetyl-CoA biphasic inhibition of medium-chain acyl-CoA dehydrogenase, rapid initial inactivation for 2 min, half-life: 1.3 min, followed by a slower decline, 95% activity lost after 30 min, no inhibition of long-chain acyl-CoA dehydrogenase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.8.1 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.1 Rattus norvegicus
-
-
-
1.3.8.5 Rattus norvegicus
-
-
-
1.3.8.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.5
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.8.1 liver
-
 Rattus norvegicus
-
1.3.8.7 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.1 butyryl-CoA + electron acceptor
-
 Rattus norvegicus 2-butenoyl-CoA + reduced acceptor
-
 ?