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Literature summary extracted from

  • Kitamura, S.; Katsura, H.; Tatsumi, K.
    Purification of a 15-ketoprostaglandin DELTA13-reductase from rat liver and its ability to reduce the double bond of xenobiotics (1993), Biochem. Mol. Biol. Int., 30, 839-847.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.48 dicoumarol 0.1 mM, complete inhibition Rattus norvegicus
1.3.1.48 indomethacin 0.1 mM, 95% inhibition Rattus norvegicus
1.3.1.48 p-chloromercuribenzoate 0.1 mM, 97% inhibition Rattus norvegicus
1.3.1.48 quercitrin 95% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.48 0.000213
-
 15-ketoprostaglandin F2alpha
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.48 39500
-
 1 * 39500, SDS-PAGE Rattus norvegicus
1.3.1.48 42000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.48 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.48 DEAE-cellulose, phenyl-toyopearl, blue-toyopearl, hydroxyapatite, liver enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.48 adrenal gland
-
 Rattus norvegicus
-
1.3.1.48 brain
-
 Rattus norvegicus
-
1.3.1.48 heart
-
 Rattus norvegicus
-
1.3.1.48 kidney
-
 Rattus norvegicus
-
1.3.1.48 liver
-
 Rattus norvegicus
-
1.3.1.48 lung
-
 Rattus norvegicus
-
1.3.1.48 pancreas
-
 Rattus norvegicus
-
1.3.1.48 small intestine
-
 Rattus norvegicus
-
1.3.1.48 spleen
-
 Rattus norvegicus
-
1.3.1.48 testis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.48 2.05
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.48 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H
-
 Rattus norvegicus (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
-
 ?
1.3.1.48 (Z)-3-[(5-methoxy-3-oxo-2(3H)-benzofuranylidene)-methyl]benzoic acid + NAD(P)H
-
 Rattus norvegicus 3-[(5-methoxy-3-oxo-2,3-dihydro-1-benzofuran-2-yl)methyl]benzoic acid + NAD(P)+
-
 ?
1.3.1.48 1-(p-carboxyphenyl)-5-cyano-3-oxo-1-pentene + NAD(P)H
-
 Rattus norvegicus 1-(p-carboxyphenyl)-5-cyano-3-oxo-pentane + NAD(P)+
-
 ?
1.3.1.48 11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H
-
 Rattus norvegicus 11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+
-
 ?
1.3.1.48 15-ketoprostaglandin F1alpha + NAD(P)H
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 15-ketoprostaglandin F2alpha + NADPH
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 beta-ionone + NAD(P)H
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 curcumin + NAD(P)H
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 trans-2-(o-hydroxybenzylidene)acetophenone + NAD(P)H
-
 Rattus norvegicus (o-hydroxybenzyl)acetophenone + NAD(P)+
-
 ?
1.3.1.48 trans-2-benzylidenecyclohexan-2-one + NAD(P)H
-
 Rattus norvegicus benzylcyclohexan-2-one + NAD(P)+
-
 ?
1.3.1.48 trans-2-butenal + NAD(P)H
-
 Rattus norvegicus butanal + NAD(P)+
-
 ?
1.3.1.48 trans-2-hexenal + NAD(P)H
-
 Rattus norvegicus hexanal + NAD(P)+
-
 ?
1.3.1.48 trans-3-(2-furyl)acrolein + NAD(P)H
-
 Rattus norvegicus 2-furylpropanal + NAD(P)+
-
 ?
1.3.1.48 trans-4-furyl-3-buten-2-one + NAD(P)H
-
 Rattus norvegicus 4-furyl-butane-2-one + NAD(P)+
-
 ?
1.3.1.48 trans-benzylideneacetone + NAD(P)H
-
 Rattus norvegicus benzylacetone + NAD(P)+
-
 ?
1.3.1.48 trans-benzylideneacetophenone + NAD(P)H
-
 Rattus norvegicus benzylacetophenone + NAD(P)+
-
 ?
1.3.1.48 trans-cinnamaldehyde + NAD(P)H
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 trans-cinnamic acid ethyl ester + NAD(P)H
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 trans-cinnamoyl thiophene + NAD(P)H
-
 Rattus norvegicus ?
-
 ?
1.3.1.48 trans-methylvinylketone + NAD(P)H
-
 Rattus norvegicus butane-2-one + NAD(P)+
-
 ?
1.3.1.48 trans-phenyl-1-propenyl ketone + NAD(P)H
-
 Rattus norvegicus phenylpropane-1-one + NAD+
-
 ?
1.3.1.48 trans-trans-2,4-hexadienal + NAD(P)H
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.48 monomer 1 * 39500, SDS-PAGE Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.1.48 6.5 8
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.48 NAD(P)H in crude extracts: NADH is 30% as effective as NADPH, in purified enzyme: NADH is 10% as effectic as NADPH Rattus norvegicus