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Literature summary extracted from

  • Xia, T.; Jensen, R.A.
    A single cyclohexadienyl dehydrogenase specifies the prephenate dehydrogenase and arogenate dehydrogenase components of the dual pathways to L-tyrosine in Pseudomonas aeruginosa (1990), J. Biol. Chem., 265, 20033-20036.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.43 L-tyrosine competitive inhibition Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.43 0.07
-
 prephenate
-
 Pseudomonas aeruginosa
1.3.1.43 0.17
-
 L-arogenate
-
 Pseudomonas aeruginosa
1.3.1.43 0.25
-
 NAD+
-
 Pseudomonas aeruginosa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.43 25500
-
 6 * 25500, SDS-PAGE Pseudomonas aeruginosa
1.3.1.43 150000
-
 gel filtration Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.43 L-arogenate + NAD+ Pseudomonas aeruginosa
-
 L-tyrosine + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.43 Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.43
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.43 L-arogenate + NAD(P)+
-
 Pseudomonas aeruginosa L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.43 L-arogenate + NAD+
-
 Pseudomonas aeruginosa L-tyrosine + NADH + CO2
-
 ?
1.3.1.43 additional information activity with prephenate and L-arogenate is unseparable during purification, thus cyclohexadienyl dehydrogenase activity Pseudomonas aeruginosa ?
-
 ?
1.3.1.43 prephenate + NAD(P)+
-
 Pseudomonas aeruginosa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.43 hexamer 6 * 25500, SDS-PAGE Pseudomonas aeruginosa

Synonyms

EC Number Synonyms Comment Organism
1.3.1.43 cyclohexadienyl dehydrogenase
-
 Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.43 NAD+
-
 Pseudomonas aeruginosa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.43 0.05
-
 L-tyrosine with L-arogenate as variable substrate, competitive inhibition Pseudomonas aeruginosa
1.3.1.43 0.06
-
 L-tyrosine with prephenate as variable substrate, competitive inhibition Pseudomonas aeruginosa