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Literature summary extracted from

  • Fazel, A.M.; Bowen, J.R.; Jensen, R.A.
    Arogenate (pretyrosine) is an obligatory intermediate of L-tyrosine biosynthesis: confirmation in a microbial mutant (1980), Proc. Natl. Acad. Sci. USA, 77, 1270-1273.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.43 additional information spontaneous mutant tyrB2 without any activity [Brevibacterium] flavum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.43 L-arogenate + NAD+ [Brevibacterium] flavum i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine L-tyrosine + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.43 [Brevibacterium] flavum
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.43 0.0134
-
-
 [Brevibacterium] flavum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.43 L-arogenate + NAD(P)+
-
 [Brevibacterium] flavum L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.43 L-arogenate + NAD+ i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine [Brevibacterium] flavum L-tyrosine + NADH + CO2
-
 ?