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Literature summary extracted from

  • Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.
    Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase (1985), Arch. Biochem. Biophys., 237, 535-544.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.8 trans-2-hexenoyl-CoA competitive inhibition of crotonoyl-CoA reduction, but not of 2-trans-hexadecenoyl-CoA and 2-trans-decenoyl-CoA reduction Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.8 0.0005
-
 2-trans-hexenoyl-CoA
-
 Rattus norvegicus
1.3.1.8 0.0011
-
 2-trans-hexadecenoyl-CoA
-
 Rattus norvegicus
1.3.1.8 0.01
-
 NADPH
-
 Rattus norvegicus
1.3.1.8 0.02
-
 crotonyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.8 microsome
-
 Rattus norvegicus
-
-
1.3.1.38 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.8 Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-
1.3.1.38 Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 not yet possible
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.8 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.8 liver
-
 Rattus norvegicus
-
1.3.1.38 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.8 1.54
-
 partially purified Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.8 2-trans-decenoyl-CoA + NAD(P)H
-
 Rattus norvegicus decanoyl-CoA + NADP+
-
 ?
1.3.1.8 2-trans-dodecenoyl-CoA + NAD(P)H
-
 Rattus norvegicus dodecanoyl-CoA + NAD(P)+
-
 ?
1.3.1.8 2-trans-hexadecenoyl-CoA + NADPH
-
 Rattus norvegicus hexadecanoyl CoA + NADP+
-
 ?
1.3.1.8 2-trans-hexenoyl-CoA + NAD(P)H
-
 Rattus norvegicus hexanoyl-CoA + NADP+
-
 ?
1.3.1.8 2-trans-octenoyl-CoA + NAD(P)H
-
 Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
1.3.1.8 2-trans-tetradecenoyl-CoA + NADPH
-
 Rattus norvegicus tetradecanoyl-CoA + NADP+
-
 ?
1.3.1.8 crotonyl-CoA + NAD(P)H
-
 Rattus norvegicus butanoyl-CoA + NADP+
-
 ?
1.3.1.8 additional information NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?
1.3.1.38 additional information NADPH-specific trans-enoyl-CoA reductases from rat liver miochondria and microsomes impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.8 trans-2-enoyl-CoA reductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.8 NADPH inactive with NADH Rattus norvegicus