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Literature summary extracted from

  • Bernert, J.T.; Sprecher, H.
    An analysis of partial reactions in the overall chain elongation of saturated and unsaturated fatty acids by rat liver microsomes (1977), J. Biol. Chem., 252, 6736-6744.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.8 additional information bovine serum albumin in assay mixture elevated the activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.8 2-trans-octadecenoyl-CoA without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM Rattus norvegicus
1.3.1.8 palmitoyl-CoA without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.8 microsome
-
 Rattus norvegicus
-
-
1.3.1.38 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.8 Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-
1.3.1.38 Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 not yet possible
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.8 liver
-
 Rattus norvegicus
-
1.3.1.38 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.8 2-trans-8,11-eicosatrienoyl-CoA + NADPH fat-free dietary elevates the activity Rattus norvegicus 8,11-eicosadienoyl-CoA + NADP+
-
 ?
1.3.1.8 2-trans-hexadecenoyl-CoA + NADPH
-
 Rattus norvegicus hexadecanoyl CoA + NADP+
-
 ?
1.3.1.8 2-trans-octadecenoyl-CoA + NAD(P)H i.e. 2-trans-oleoyl-CoA Rattus norvegicus octadecanoyl-CoA + NAD(P)+
-
 ?
1.3.1.8 2-trans-octenoyl-CoA + NAD(P)H
-
 Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
1.3.1.8 6,9-octadecadienoyl-CoA + NADPH fat-free dietary elevates the activity Rattus norvegicus ?
-
 ?
1.3.1.8 additional information NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?
1.3.1.38 additional information NADPH-specific trans-enoyl-CoA reductases from rat liver miochondria and microsomes impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.8 2-trans-enoyl-CoA reductase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.8 8.3
-
 in HEPES and Bicine buffer Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.8 NADPH inactive with NADH Rattus norvegicus